| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Evaluation of the Hypnotic and Hemodynamic Effects of Dexmedetomidine on Propofol-Sedated Swine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
dexmedetomidine |
| キーワード |
|
|
主題 |
propofol |
| キーワード |
|
|
主題 |
swine |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
プロポフォール鎮静下のブタにおけるデクスメデトミジンの鎮静効果、血行動態の評価 |
| 著者 |
SANO, Hideki
DOI, Matsuyuki
MIMURO, Soichiro
YU, Shuchun
KURITA, Tadayoshi
SATO, Shigehito
|
| 書誌情報 |
en : Experimental Animals
巻 59,
号 2,
p. 199-205,
発行日 2010-04
|
| 出版者 |
|
|
出版者 |
日本実験動物学会 Japanese Association for Laboratory Animal Sciences |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
Copyright 2010 日本実験動物学会 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
This study examined the sedative effect of, and hemodynamic response to dexmedetomidine administration in propofol-sedated swine. Sixteen swine were subjects. After anesthetic induction and preparation, the propofol infusion rate was adjusted to maintain a bispectral index (BIS) value between 55 and 65 (i.e., baseline). With the propofol infusion rate fixed at the baseline rate, dexmedetomidine was infused continuously at a rate of 0.2, 0.4, and 0.7 μg・kg -1・h-1 for one hour at each rate. The BIS value and hemodynamic parameters were recorded at each step. Dexmedetomidine decreased the BIS value, mean arterial blood pressure, heart rate, cardiac output, and mixed venous oxygen saturation in a dose-dependent manner. The systemic vascular resistance (SVR) did not change, but the pulmonary vascular resistance (PVR) increased. Oxygen delivery (DO2) and oxygen consumption (VO2) decreased. A small dose of dexmedetomidine (0.2 μg・kg-1・h-1) greatly enhanced the sedative effects of propofol with only small changes in hemodynamics and systemic oxygen balance, suggesting it may be useful in reducing the propofol dose requirement. However, dexmedetomidine 0.4 μg・kg-1・h-1 suppressed cardiac contractility, and 0.7 μg・kg-1・h-1 induced hemodynamic instability and further systemic oxygen imbalance while the additional sedative effect was limited. A lower dose of dexmedetomidine may be recommended when using it in combination with propofol. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13411357 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18817122 |
| 出版社DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1538/expanim.59.199 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ExpAnim-59_2-199.pdf (418.3 kB)
