{"_buckets": {"deposit": "27c1c997-b3ef-4ce0-b221-46e9bd1220c4"}, "_deposit": {"created_by": 4, "id": "2000039", "owner": "4", "owners": [4], "owners_ext": {"displayname": "浜医大図書館", "username": "hamamed"}, "pid": {"revision_id": 0, "type": "depid", "value": "2000039"}, "status": "published"}, "_oai": {"id": "oai:hama-med.repo.nii.ac.jp:02000039", "sets": ["17"]}, "author_link": [], "control_number": "2000039", "item_5_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "線条体外ドーパミンD2/3受容体の結合、機能的結合性と自閉症の社会コミュニケーション障害：PETとfMRI研究", "subitem_alternative_title_language": "ja"}]}, "item_5_biblio_info_5": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "2113", "bibliographicPageStart": "2106", "bibliographicVolumeNumber": "27", "bibliographic_titles": [{"bibliographic_title": "Molecular Psychiatry", "bibliographic_titleLang": "en"}]}]}, "item_5_date_granted_17": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2022-03-14"}]}, "item_5_degree_grantor_15": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "浜松医科大学"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13802", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_5_degree_name_12": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）", "subitem_degreename_language": "ja"}]}, "item_5_description_13": {"attribute_name": "学位の区分", "attribute_value_mlt": [{"subitem_description": "doctoral", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_5_description_14": {"attribute_name": "学位の分野", "attribute_value_mlt": [{"subitem_description": "医学系研究科", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_5_description_16": {"attribute_name": "報告番号", "attribute_value_mlt": [{"subitem_description": "甲第906号", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_5_description_9": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The social motivation hypothesis of autism proposes that social communication symptoms in autism spectrum disorder (ASD) stem from atypical social attention and reward networks, where dopamine acts as a crucial mediator. However, despite evidence indicating that individuals with ASD show atypical activation in extrastriatal regions while processing reward and social stimuli, no previous studies have measured extrastriatal dopamine D2/3 receptor (D2/3R) availability in ASD. Here, we investigated extrastriatal D2/3R availability in individuals with ASD and its association with ASD social communication symptoms using positron emission tomography (PET). Moreover, we employed a whole-brain multivariate pattern analysis of resting-state functional magnetic resonance imaging (fMRI) to identify regions where functional connectivity atypically correlates with D2/3R availability depending on ASD diagnosis. Twenty-two psychotropic-free males with ASD and 24 age- and intelligence quotient-matched typically developing males underwent [11C]FLB457 PET, fMRI, and clinical symptom assessment. Participants with ASD showed lower D2/3R availability throughout the D2/3R-rich extrastriatal regions of the dopaminergic pathways. Among these, the posterior region of the thalamus, which primarily comprises the pulvinar, displayed the largest effect size for the lower D2/3R availability, which correlated with a higher score on the Social Affect domain of the Autism Diagnostic Observation Schedule-2 in participants with ASD. Moreover, lower D2/3R availability was correlated with lower functional connectivity of the thalamus-superior temporal sulcus and cerebellum-medial occipital cortex, specifically in individuals with ASD. The current findings provide novel molecular evidence for the social motivation theory of autism and offer a novel therapeutic target.", "subitem_description_language": "en"}]}, "item_5_dissertation_number_18": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第906号"}]}, "item_5_publisher_6": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Nature", "subitem_publisher_language": "en"}]}, "item_5_relation_26": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "35181754", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_28": {"attribute_name": "出版社DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/s41380-022-01464-3", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_7": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41380-022-01464-3", "subitem_rights_language": "en"}]}, "item_5_select_2": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_select_item": "Thesis or Dissertation", "subitem_select_language": "en"}]}, "item_5_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1359-4184", "subitem_source_identifier_type": "PISSN"}]}, "item_5_source_id_20": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1476-5578", "subitem_source_identifier_type": "EISSN"}]}, "item_5_version_type_32": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "村山, 千尋", "creatorNameLang": "ja"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2023-11-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "DT_906ronbun.pdf", "filesize": [{"value": "5.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 5600000.0, "url": {"label": "論文本文", "objectType": "fulltext", "url": "https://hama-med.repo.nii.ac.jp/record/2000039/files/DT_906ronbun.pdf"}, "version_id": "5005a684-b3e0-43b8-aaad-093f6e744989"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Extrastriatal dopamine D2/3 receptor binding, functional connectivity, and autism socio-communicational deficits: a PET and fMRI study", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Extrastriatal dopamine D2/3 receptor binding, functional connectivity, and autism socio-communicational deficits: a PET and fMRI study", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "4", "path": ["17"], "permalink_uri": "http://hdl.handle.net/10271/0002000039", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2023-11-15"}, "publish_date": "2023-11-15", "publish_status": "0", "recid": "2000039", "relation": {}, "relation_version_is_last": true, "title": ["Extrastriatal dopamine D2/3 receptor binding, functional connectivity, and autism socio-communicational deficits: a PET and fMRI study"], "weko_shared_id": -1}