A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction

Yesmin, Mst Ruksana

doi:https://doi.org/10.3389/fnmol.2022.990803

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A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction

http://hdl.handle.net/10271/0002000065

名前 / ファイル	ライセンス	アクション
論文本文 (9.3 MB)

Item type

学位論文 / Thesis or Dissertation(1)

公開日

2023-12-26

タイトル

A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction

言語

eng

キーワード

主題

CRH neuron

キーワード

主題

paraventricular nucleus

キーワード

主題

median eminence

キーワード

主題

AgRP neuron

キーワード

主題

arcuate nucleus

キーワード

主題

NKCC1

キーワード

主題

HPA axis

キーワード

主題

corticosterone

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_db06

資源タイプ

doctoral thesis

アクセス権

open access

アクセス権URI

http://purl.org/coar/access_right/c_abf2

その他のタイトル

アグーチ関連ペプチドニューロンの亜集団は食物制限に応答し正中隆起のコルチコトロピン放出ホルモン軸索終末を興奮させ視床下部-下垂体-副腎軸を活性化する

著者

Yesmin, Mst Ruksana

書誌情報

en : Frontiers in Molecular Neuroscience

巻 15, p. 990803, 発行日 2022-09-29

出版者

Frontiers Media S.A.

言語

権利

言語

権利情報

Copyright 2022 Yesmin, Watanabe, Sinha, Ishibashi, Wang and Fukuda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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内容記述タイプ

Abstract

内容記述

The excitatory action of gamma-aminobutyric-acid (GABA) in the median-eminence (ME) led to the steady-state release of corticotropin-releasing hormone (CRH) from CRH axon terminals, which modulates the hypothalamic-pituitary-adrenal (HPA) axis. However, in ME, the source of excitatory GABAergic input is unknown. We examined agouti-related peptide (AgRP) expressing neurons in the arcuate nucleus as a possible source for excitatory GABAergic input. Here, we show that a subpopulation of activated AgRP neurons directly project to the CRH axon terminals in ME elevates serum corticosterone levels in 60% food-restricted mice. This increase in serum corticosterone is not dependent on activation of CRH neuronal soma in the paraventricular nucleus. Furthermore, conditional deletion of NaC-KC-2Cl⁻ cotransporter-1 (NKCC1), which promotes depolarizing GABA action, from the CRH axon terminals results in significantly lower corticosterone levels in response to food restriction. These findings highlight the important role of a subset of AgRP neurons in HPA axis modulation via NKCC1-dependent GABAergic excitation in ME.

言語

学位名

博士（医学）

学位の区分

内容記述

doctoral

学位の分野

内容記述

医学系研究科

学位授与機関

学位授与機関識別子Scheme

kakenhi

学位授与機関識別子

13802

学位授与機関名

浜松医科大学

学位授与年月日

2022-10-21

学位授与番号

甲第922号

EISSN

収録物識別子タイプ

EISSN

収録物識別子

1662-5099

PubMed番号

識別子タイプ

PMID

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2023-12-26 07:08:35.071341

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A subpopulation of agouti-related peptide neurons exciting corticotropin-releasing hormone axon terminals in median eminence led to hypothalamic-pituitary-adrenal axis activation in response to food restriction

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