Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons

細井, 泰志

doi:https://doi.org/10.3389/fnmol.2022.806798

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Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons

http://hdl.handle.net/10271/0002000101

名前 / ファイル	ライセンス	アクション
DT_ron597ronbun.pdf (3.5 MB)

Item type

学位論文 / Thesis or Dissertation(1)

公開日

2024-03-08

タイトル

Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons

言語

eng

キーワード

主題

taurine

キーワード

主題

neocortex

キーワード

主題

pyramidal neurons

キーワード

主題

action potentials

キーワード

主題

taurine transporter-knockout mouse

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_db06

資源タイプ

doctoral thesis

アクセス権

open access

アクセス権URI

http://purl.org/coar/access_right/c_abf2

その他のタイトル

胎児期・生後発達期のタウリン枯渇は大脳新皮質II/III層錐体神経細胞の発火応答を鈍麻させる

著者

細井, 泰志

書誌情報

en : Frontiers in Molecular Neuroscience

巻 15, p. 806798, 発行日 2022-11-17

出版者

Frontiers Media S.A.

言語

権利

言語

権利情報

(C) 2022 Hosoi, Akita, Watanabe, Ito, Miyajima and Fukuda. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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内容記述タイプ

Abstract

内容記述

Fetal and infant brains are rich in maternally derived taurine. We previously demonstrated that taurine action regulates the cation-chloride cotransporter activity and the differentiation and radial migration of pyramidal neuron progenitors in the developing neocortex of rodent fetuses. Here we examined the effects of fetal and infantile taurine depletion caused by knockout of the taurine transporter Slc6a6 on firing properties of layer II/III pyramidal neurons in the mouse somatosensory cortex at 3 weeks of postnatal age, using the whole-cell patch-clamp technique. The membrane excitability under resting conditions was similar between the neurons in knockout mice and those in wildtype littermates. However, the frequency of repetitive spike firing during moderate current injection was significantly lower, along with lower membrane voltage levels during interspike intervals in knockout neurons. When strong currents were injected, by which repetitive firing was rapidly abolished due to inactivation of voltage-gated Na+ channels in wildtype neurons, the firing in knockout neurons lasted for a much longer period than in wildtype neurons. This was due to much lower membrane voltage levels during interspike intervals in knockout neurons, promoting greater recovery of voltage-gated Na+ channels from inactivation. Thus, taurine depletion in pyramidal neurons blunted neuronal responses to external stimuli through increasing the stability of repetitive firing, presumably mediated by larger increases in membrane K+ conductance during interspike intervals.

言語

学位名

博士（医学）

学位の区分

内容記述

doctoral

学位の分野

内容記述

医学系研究科

学位授与機関

学位授与機関識別子Scheme

kakenhi

学位授与機関識別子

13802

学位授与機関名

浜松医科大学

学位授与年月日

2023-03-09

学位授与番号

乙第597号

EISSN

収録物識別子タイプ

EISSN

収録物識別子

1662-5099

PubMed番号

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Ver.1

2024-03-08 02:20:23.583141

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Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons

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