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CD109 on dendritic cells regulates airway hyperreactivity and eosinophilic airway inflammation
http://hdl.handle.net/10271/0002000105
http://hdl.handle.net/10271/0002000105da330ea3-1232-4a95-831b-0b1b4b114d70
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DT_928ronbun.pdf (2.8 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2024-03-11 | |||||||||||
| タイトル | ||||||||||||
| タイトル | CD109 on dendritic cells regulates airway hyperreactivity and eosinophilic airway inflammation | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | Asthma | |||||||||||
| キーワード | ||||||||||||
| 主題 | CD109 | |||||||||||
| キーワード | ||||||||||||
| 主題 | dendritic cell | |||||||||||
| キーワード | ||||||||||||
| 主題 | airway hyperreactivity | |||||||||||
| キーワード | ||||||||||||
| 主題 | eosinophil inflammation | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| その他のタイトル | ||||||||||||
| その他のタイトル | 樹状細胞上のCD109分子は、気道過敏性および好酸球性気道炎症を制御する | |||||||||||
| その他のタイトル | ||||||||||||
| その他のタイトル | CD109 on DCs regulates asthma | |||||||||||
| 著者 |
青野, 祐也
× 青野, 祐也
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| 書誌情報 |
en : American Journal of Respiratory Cell and Molecular Biology 巻 68, 号 2, p. 201-212, 発行日 2023-02 |
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| 出版者 | ||||||||||||
| 出版者 | American Thoracic Society | |||||||||||
| 言語 | en | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | Originally Published in: Yuya Aono [etc]. Article Title: CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation. Journal Name: American Journal of Respiratory Cell and Molecular Biology, 2022; Volume 23: Pages 8996. DOI: 10.1165/rcmb.2022-0109OC. Copyright (C)2023 by the American Thoracic Society The final publication is available at [https://www.atsjournals.org/doi/abs/10.1165/rcmb.2022-0109OC]. | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Asthma is a chronic airway inflammatory disease characterized by airway hyperreactivity (AHR) and eosinophilic airway inflammation. Dendritic cells (DCs) are essential for the development of asthma via presenting allergens, causing Th2 skewing and eosinophil inflammation. Recent studies have revealed that CD109, a glycosylphosphatidylinositolanchored glycoprotein, is involved in the pathogenesis of inflammatory diseases such as rheumatoid arthritis and psoriasis. However, no study has addressed the role of CD109 in asthma. This study sought to address the role of CD109 on DCs in the development of AHR and allergic inflammation. CD109 deficient mice (CD109−/− mice) were sensitized with house dust mite (HDM) or ovalbumin and compared to wild-type (WT) mice for induction of AHR and allergic inflammation. CD109-deficient mice had reduced AHR and eosinophilic inflammation together with lower Th2 cytokine expression compared to WT mice. Interestingly, CD109 expression was induced in lung conventional DC2s (cDC2s), but not lung cDC1s, upon allergic challenge. Lung cDC2s from CD109−/− mice had a poor ability to induce cytokine production in ex vivo DC-T cell cocultures with high expression of RUNX3, resulting in suppression of Th2 differentiation. Adoptive transfer of bone-marrow-derived CD109−/− DCs loaded with HDM failed to develop AHR and eosinophilic inflammation. Finally, administration of monoclonal anti-CD109 antibody reduced airway eosinophils and significantly decreased AHR. Our results suggest the involvement of CD109 in asthma pathogenesis. CD109 is a novel therapeutic target for asthma. | |||||||||||
| 言語 | en | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位の区分 | ||||||||||||
| 内容記述 | dotoral | |||||||||||
| 学位の分野 | ||||||||||||
| 内容記述 | 医学系研究科 | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 13802 | |||||||||||
| 学位授与機関名 | 浜松医科大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2023-03-16 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第928号 | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 1044-1549 | |||||||||||
| EISSN | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 1535-4989 | |||||||||||
| NII書誌ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA10707251 | |||||||||||
| PubMed番号 | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 36215676 | |||||||||||
| 出版社DOI | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1165/rcmb.2022-0109OC | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
