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Optimal method for measuring invasive size that predicts survival in invasive mucinous adenocarcinoma of the lung
http://hdl.handle.net/10271/0002000254
http://hdl.handle.net/10271/000200025477c65628-aff0-4939-8cc9-644d48a9f96f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (2 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2024-12-20 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Optimal method for measuring invasive size that predicts survival in invasive mucinous adenocarcinoma of the lung | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | Invasive mucinous adenocarcinoma | |||||||||||
| キーワード | ||||||||||||
| 主題 | invasive size | |||||||||||
| キーワード | ||||||||||||
| 主題 | lepidic component | |||||||||||
| キーワード | ||||||||||||
| 主題 | TNM classification | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| その他のタイトル | ||||||||||||
| その他のタイトル | 浸潤性粘液性肺腺癌の予後を予測する最適な浸潤径の測定方法 | |||||||||||
| 著者 |
沖, 智成
× 沖, 智成
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| 書誌情報 |
en : Journal of Cancer Research and Clinical Oncology 巻 146, 号 5, p. 1291-1298 |
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| 出版者 | ||||||||||||
| 出版者 | Springer Nature | |||||||||||
| 言語 | en | |||||||||||
| 権利 | ||||||||||||
| 言語 | en | |||||||||||
| 権利情報 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00432-020-03158-1 | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Purpose The purpose of this study was to determine the optimal method for measuring pathological invasive size that predicts prognosis in invasive mucinous adenocarcinoma (IMA). Methods We analyzed patients who underwent complete surgical resection for lung IMA. The invasive size of IMA was measured using two methods: (1) excluding lepidic method (ELM), that is, lepidic component was excluded from the invasive area regardless of alveolar mucin and (2) including lepidic method (ILM), that is, lepidic component was included as invasive area if alveolar space was filled with mucin. The prognostic predictability of ELM and ILM on survival was assessed using univariable and multivariable Cox regression models. The discriminative power was assessed using concordance probability estimate (CPE) and Akaike’s information criteria (AIC), and the prognostic impact of the newly redefined pathological stage according to ELM or ILM was also assessed. Results A total of 101 patients were included. The median invasive size via ELM and ILM was 1.4cm (range, 0.0-7.7cm) and 2.1cm (range, 0.0-14.2cm), respectively. ELM had better discriminative power than ILM (ELM, HR=1.38, AIC=110.19, CPE=0.671; ILM, HR=1.19, AIC=111.52, CPE=0.655). Although the survival curves based on ILM crossed between T3 and T4, the overall survival (OS) curves based on ELM were sufficiently distinct from one another. Conclusions ELM has higher discriminative power for OS, and thus the optimal method for measuring the pathological invasive size of IMA should exclude the lepidic component regardless of alveolar mucin. |
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| 言語 | en | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位の区分 | ||||||||||||
| 内容記述 | doctoral | |||||||||||
| 学位の分野 | ||||||||||||
| 内容記述 | 医学系研究科 | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 13802 | |||||||||||
| 学位授与機関名 | 浜松医科大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2024-01-19 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 乙第605号 | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0171-5216 | |||||||||||
| EISSN | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 1432-1335 | |||||||||||
| NII書誌ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA0025708X | |||||||||||
| PubMed番号 | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 32088782 | |||||||||||
| 出版社DOI | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1007/s00432-020-03158-1 | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
