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High expression of Fas-associated factor 1 indicates a poor prognosis in non-small-cell lung cancer
http://hdl.handle.net/10271/0002000312
http://hdl.handle.net/10271/00020003120e08d58f-dcd8-4b8f-a78a-db09a62f5986
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (2.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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| 公開日 | 2025-02-10 | |||||||||
| タイトル | ||||||||||
| タイトル | High expression of Fas-associated factor 1 indicates a poor prognosis in non-small-cell lung cancer | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | FAF1 | |||||||||
| キーワード | ||||||||||
| 主題 | non-small-cell lung cancer | |||||||||
| キーワード | ||||||||||
| 主題 | prognosis | |||||||||
| キーワード | ||||||||||
| 主題 | apoptosis | |||||||||
| キーワード | ||||||||||
| 主題 | proliferation | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||
| 資源タイプ | doctoral thesis | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| その他のタイトル | ||||||||||
| その他のタイトル | Fas-associated factor 1の高発現は非小細胞肺がんの予後不良を示す | |||||||||
| 著者 |
胡, 徳
× 胡, 徳
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| 書誌情報 |
en : Current Oncology 巻 30, 号 11, p. 9484-9500, 発行日 2023-10-25 |
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| 出版者 | ||||||||||
| 出版者 | MDPI | |||||||||
| 言語 | en | |||||||||
| 権利 | ||||||||||
| 言語 | en | |||||||||
| 権利情報 | (C) 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Fas-associated factor 1 (FAF1) is a death-promoting protein identified as an interaction partner of the death receptor Fas. The downregulation and mutation of FAF1 have been reported in a variety of human tumors, but there have been few studies on lung cancer. Here, we investigated the prognostic significance of FAF1 expression in non-small-cell lung cancer (NSCLC), and whether aberrant FAF1 expression may be involved in the pathogenesis and prognosis of NSCLC. FAF1 expression was examined in NSCLC specimens as well as human lung cancer cell lines. In addition, changes in cell viability and apoptosis upon regulating FAF1 expression were investigated in lung cancer cell lines. As a result, high FAF1 expression was significantly associated with a poor prognosis in NSCLC. In lung cancer cell lines, FAF1 downregulation hindered cell viability and tended to promote early apoptosis. In conclusion, this is the first study of the clinical significance of FAF1 in NSCLC, showing that FAF1 overexpression is associated with a poor prognosis in NSCLC and that FAF1 acts as a dangerous factor rather than an apoptosis promoter in NSCLC. | |||||||||
| 言語 | en | |||||||||
| 学位名 | ||||||||||
| 学位名 | 博士（医学） | |||||||||
| 学位の区分 | ||||||||||
| 内容記述 | doctoral | |||||||||
| 学位の分野 | ||||||||||
| 内容記述 | 医学系研究科 | |||||||||
| 学位授与機関 | ||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||
| 学位授与機関識別子 | 13802 | |||||||||
| 学位授与機関名 | 浜松医科大学 | |||||||||
| 学位授与機関名 | Hamamatsu University School of Medicine | |||||||||
| 学位授与年月日 | ||||||||||
| 学位授与年月日 | 2024-02-14 | |||||||||
| 学位授与番号 | ||||||||||
| 学位授与番号 | 甲第963号 | |||||||||
| EISSN | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 1718-7729 | |||||||||
| PubMed番号 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 37999107 | |||||||||
| 出版社DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.3390/curroncol30110687 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
