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Impact of high-dose vasopressor during endotoxic shock on the cerebral, lingual, hepatic, and renal microcirculation evaluated by near-infrared spectroscopy in swine
http://hdl.handle.net/10271/0002000342
http://hdl.handle.net/10271/00020003422cc63e77-2266-4a96-8ded-77cf9eabe667
| 名前 / ファイル | ライセンス | アクション |
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Shock-61-406.pdf (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2025-02-26 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Impact of high-dose vasopressor during endotoxic shock on the cerebral, lingual, hepatic, and renal microcirculation evaluated by near-infrared spectroscopy in swine | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Endotoxic shock | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Microcirculation | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Near-infrared spectroscopy | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Norepinephrine | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Septic shock | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Vasopressin | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 著者 |
Kurita, Tadayoshi
× Kurita, Tadayoshi
× Kawashima, Shingo
× Ibrahim Khaleelullah, Mohamed Mathar Sahib
× Nakajima, Yoshiki
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| 書誌情報 |
en : SHOCK® : Injury, Inflammation, and Sepsis 巻 61, 号 3, p. 406-413, 発行日 2024-03 |
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| 出版者 | ||||||||||||||
| 出版者 | Wolters Kluwer Health | |||||||||||||
| 言語 | en | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | This is a non-final version of an article published in final form in "SHOCK, Vol.61 No.3, pp406-413". | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Background: High-dose vasopressors maintain blood pressure during septic shock but may adversely reduce microcirculation in vital organs. We assessed the effect of high-dose norepinephrine and vasopressin on the microcirculation of the brain, tongue, liver, and kidney during endotoxic shock using near-infrared spectroscopy (NIRS). Methods: Thirteen pigs (24.5 ± 1.8 kg) were anesthetized, and an NIRS probe was attached directly to each organ. Approximately 0.2, 0.5, 1, and 2 μg/kg/min of norepinephrine were administered in a stepwise manner, followed by 0.5, 1, 2, and 5μg/kg/min of sodium nitroprusside in normal condition. Moreover, 1 μg/kg/h of lipopolysaccharide was administered continuously after 100 μg bolus to create endotoxic shock, and after 1000mL of crystalloid infusion, high-dose norepinephrine (2, 5, 10, and 20 μg/kg/min) and vasopressin (0.6, 1.5, 3, and 6 U/min) were administered in a stepwise manner. The relationship between the mean arterial pressure (MAP) and each tissue oxygenation index (TOI) during vasopressor infusion was evaluated. Results: Three pigs died after receiving lipopolysaccharides, and 10 were analyzed. An increase of >20% from the baseline MAP induced by high-dose norepinephrine during endotoxic shock reduced the TOI in all organs except the liver. The elevation of MAP to baseline with vasopressin alone increased the kidney and liver TOIs and decreased the tongue TOI. Conclusions: Forced blood pressure elevation with high-dose norepinephrine during endotoxic shock decreased the microcirculation of vital organs, especially the kidney. Cerebral TOI may be useful for identifying the upper limit of blood pressure, at which norepinephrine impairs microcirculation. |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 1073-2322 | |||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 1540-0514 | |||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA12149608 | |||||||||||||
| PubMed番号 | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | 38010114 | |||||||||||||
| 出版社DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.1097/SHK.0000000000002282 | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
