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  1. 学術雑誌論文
  2. 各雑誌掲載論文
  1. 学術雑誌論文
  2. 浜松医科大学優秀論文賞

Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation

http://hdl.handle.net/10271/0002000384
http://hdl.handle.net/10271/0002000384
0b5b1d43-3d89-4c72-a9c6-3eb35a33832a
名前 / ファイル ライセンス アクション
優秀_JHEP JHEP Rep-7-101225.pdf (1.5 MB)
license.icon
Item type 学術雑誌論文 / Journal Article(1)
公開日 2025-04-15
タイトル
タイトル Induction of phospholipase A2 group 4C by HCV infection regulates lipid droplet formation
言語 en
言語
言語 eng
キーワード
主題 HCV
キーワード
主題 liver steatosis
キーワード
主題 human hepatocyte chimeric mice
キーワード
主題 lipidome analysis
キーワード
主題 PLA2G4C
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 Ito, Masahiko

× Ito, Masahiko

en Ito, Masahiko
Hamamatsu University School of Medicine

ja ISNI 浜松医科大学 0000000089376696

ja-Kana ハママツイカダイガク

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Liu, Jie

× Liu, Jie

en Liu, Jie

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Fukasawa, Masayoshi

× Fukasawa, Masayoshi

en Fukasawa, Masayoshi
National Institute of Infectious Diseases

ja ISNI 国立感染症研究所 0000000122201880

ja-Kana コクリツカンセンショウケンキュウジョ

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Tsutsumi, Koji

× Tsutsumi, Koji

en Tsutsumi, Koji
Kitasato University

ja ISNI 北里大学 0000000092062938

ja-Kana キタサトダイガク

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Kanegae , Yumi

× Kanegae , Yumi

en Kanegae , Yumi
Jikei University School of Medicine

ja ISNI 東京慈恵会医科大学 0000000417567986

ja-Kana トウキョウジケイカイイカダイガク

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Setou, Mitsutoshi

× Setou, Mitsutoshi

en Setou, Mitsutoshi

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Kohara, Michinori

× Kohara, Michinori

en Kohara, Michinori
Tokyo Metropolitan Institute of Medical Science

ja ISNI 東京都医学総合研究所 0000000121784383

ja-Kana トウキョウトイガクソウゴウケンキュウジョ

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Suzuki, Tetsuro

× Suzuki, Tetsuro

en Suzuki, Tetsuro

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書誌情報 en : JHEP Reports

巻 7, 号 1, p. 101225, 発行日 2024-12-16
出版者
出版者 Elsevier
言語 en
権利
権利情報 (C) 2024 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). This is an open access article under the CC BYNC- ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
抄録
内容記述タイプ Abstract
内容記述 Background & Aims: Hepatic steatosis, characterized by lipid accumulation in hepatocytes, is a key diagnostic feature in patients with chronic hepatitis C virus (HCV) infection. This study aimed to clarify the involvement of phospholipid metabolic pathways in the pathogenesis of HCV-induced steatosis.
Methods: The expression and distribution of lipid species in the livers of human liver chimeric mice were analyzed using imaging mass spectrometry. Triglyceride accumulation and lipid droplet formation were studied in phospholipase A2 group 4C (PLA2G4C) knockout or overexpressing cells.
Results: Imaging mass spectrometry of the infected mouse model revealed increased lysophosphatidylcholine levels and decreased phosphatidylcholine levels in HCV-positive regions of the liver. Among the transcripts associated with phosphatidylcholine biosynthesis, upregulation of PLA2G4C mRNA was most pronounced following HCV infection. Activation of the transcription factor NF-jB and upregulation of c-Myc were important for activation of PLA2G4C transcription by HCV infection and expression of the viral proteins Core-NS2. The amount and size of lipid droplets were reduced in PLA2G4C-knockout cells. Inhibition of NF-jB or c-Myc activity suppressed lipid droplet formation in HCV-infected cells. HCV infection promoted the stabilization of lipid droplets, but this stability was reduced in PLA2G4C-knockout cells. Overexpression of PLA2G4C decreased the levels of phosphatidylcholine species in the lipid droplet fraction and led to lower levels of key factors involved in lipolysis (breakdown of triglycerides into glycerol and free fatty acids), such as ATGL, PLIN1 and ABHD5 on the lipid droplets.
Conclusions: HCV infection markedly increases PLA2G4C expression. This may alter the phospholipid composition of the lipid droplet membrane, leading to stabilization and enlargement of the droplets.
注記
内容記述 令和6年 浜松医科大学優秀論文賞:優秀論文賞
受賞者:伊藤 昌彦
EISSN
収録物識別子タイプ EISSN
収録物識別子 2589-5559
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 39802806
出版社DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jhepr.2024.101225
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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