| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-04-15 |
| タイトル |
|
|
タイトル |
3D-CT-derived lung volumes and mortality risk in patients with fibrotic hypersensitivity pneumonitis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Hypersensitivity pneumonitis |
| キーワード |
|
|
主題 |
Inciting antigen |
| キーワード |
|
|
主題 |
Lung volume |
| キーワード |
|
|
主題 |
Mortality |
| キーワード |
|
|
主題 |
Three-dimensional computed tomography |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Yazawa, Shusuke
Suzuki, Yuzo
Tanaka, Yuko
Yokomura, Koshi
Kono, Masato
Hashimoto, Dai
Fukada, Atsuki
Inoue, Yusuke
Yasui, Hideki
Hozumi, Hironao
Karayama, Masato
Furuhashi, Kazuki
Enomoto, Noriyuki
Fujisawa, Tomoyuki
Inui, Naoki
Suda, Takafumi
|
| 書誌情報 |
en : Allergology International
巻 74,
号 1,
p. 78-85,
発行日 2025-01-03
|
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
日本アレルギー学会 |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
(C) 2024 Japanese Society of Allergology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Hypersensitivity pneumonitis (HP) is a complex and heterogenous interstitial lung disease (ILD) that occurs in susceptible individuals due to certain inhaled antigens. Fibrotic-HP is a major underlying disease of progressive pulmonary fibrosis. Therefore, in addition to the radiological features of HP, quantitatively measuring fibrosis is important to evaluate disease severity and progression. The present study aimed to compare three-dimensional computed tomography (3D-CT)-derived lung volumes (LVs) of patients with HP and determine its association with mortality risk.
Methods: In this retrospective and multicenter cohort study, 126 patients diagnosed with HP (fibrotic, n=72 and non-fibrotic, n=54) with a confidence level higher than moderate were enrolled. Each lobe LV was measured using 3D-CT at the time of diagnosis and standardized using predicted forced vital capacity. The 3D-CT LV was compared with those of 42 controls and 140 patients with idiopathic pulmonary fibrosis (IPF).
Results: Compared to patients with fibrotic-HP, the standardized total LV was significantly higher in controls and patients with non-fibrotic-HP and was similar in patients with IPF. Longitudinal analyses demonstrated that approximately half of the patients with fibrotic-HP had an annual decrease in total LV. Decreased total and lower-lobe LVs were associated with shorter survival, and were independently associated with mortality together with ongoing exposure to inciting antigens. A composite model consisting of ongoing exposure to inciting antigens and total or lower-lobe LV successfully classified mortality risk into three groups.
Conclusions: Quantitatively measuring standardized LV can help determine disease severity, progression, and mortality risk in patients with fibrotic-HP. |
| 注記 |
|
|
内容記述 |
令和6年 浜松医科大学論文賞：優秀論文賞（学生特別枠）
受賞者：矢澤 秀介 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1323-8930 |
| EISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1440-1592 |
| NII書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11091750 |
| PubMed番号 |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
39242341 |
| 出版社DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.alit.2024.07.002 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
AI-74-78.pdf (1.4 MB)
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