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  1. 学術雑誌論文
  2. 各雑誌掲載論文
  1. 学術雑誌論文
  2. 浜松医科大学優秀論文賞

3D-CT-derived lung volumes and mortality risk in patients with fibrotic hypersensitivity pneumonitis

http://hdl.handle.net/10271/0002000385
http://hdl.handle.net/10271/0002000385
94b15749-725a-4b47-ac9c-745e843242f2
名前 / ファイル ライセンス アクション
優秀_学生枠_AI-74-78.pdf AI-74-78.pdf (1.4 MB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2025-04-15
タイトル
タイトル 3D-CT-derived lung volumes and mortality risk in patients with fibrotic hypersensitivity pneumonitis
言語 en
言語
言語 eng
キーワード
主題 Hypersensitivity pneumonitis
キーワード
主題 Inciting antigen
キーワード
主題 Lung volume
キーワード
主題 Mortality
キーワード
主題 Three-dimensional computed tomography
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 Yazawa, Shusuke

× Yazawa, Shusuke

en Yazawa, Shusuke
Hamamatsu University School of Medicine

ja ISNI 浜松医科大学 0000000089376696

ja-Kana ハママツイカダイガク

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Suzuki, Yuzo

× Suzuki, Yuzo

en Suzuki, Yuzo

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Tanaka, Yuko

× Tanaka, Yuko

en Tanaka, Yuko

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Yokomura, Koshi

× Yokomura, Koshi

en Yokomura, Koshi
Seirei Mikatahara General Hospital

ja ISNI 聖隷三方原病院 0000000417648727

ja-Kana セイレイミカタハラビョウイン

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Kono, Masato

× Kono, Masato

en Kono, Masato
Seirei Hamamatsu General Hospital

ja ISNI 聖隷浜松病院 0000000403778408

ja-Kana セイレイハママツビョウイン

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Hashimoto, Dai

× Hashimoto, Dai

en Hashimoto, Dai

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Fukada, Atsuki

× Fukada, Atsuki

en Fukada, Atsuki

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Inoue, Yusuke

× Inoue, Yusuke

en Inoue, Yusuke

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Yasui, Hideki

× Yasui, Hideki

en Yasui, Hideki

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Hozumi, Hironao

× Hozumi, Hironao

en Hozumi, Hironao

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Karayama, Masato

× Karayama, Masato

en Karayama, Masato

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Furuhashi, Kazuki

× Furuhashi, Kazuki

en Furuhashi, Kazuki

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Enomoto, Noriyuki

× Enomoto, Noriyuki

en Enomoto, Noriyuki

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Fujisawa, Tomoyuki

× Fujisawa, Tomoyuki

en Fujisawa, Tomoyuki

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Inui, Naoki

× Inui, Naoki

en Inui, Naoki

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Suda, Takafumi

× Suda, Takafumi

en Suda, Takafumi

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書誌情報 en : Allergology International

巻 74, 号 1, p. 78-85, 発行日 2025-01-03
出版者
出版者 Elsevier
言語 en
出版者
出版者 日本アレルギー学会
言語 ja
権利
権利情報 (C) 2024 Japanese Society of Allergology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
抄録
内容記述タイプ Abstract
内容記述 Background: Hypersensitivity pneumonitis (HP) is a complex and heterogenous interstitial lung disease (ILD) that occurs in susceptible individuals due to certain inhaled antigens. Fibrotic-HP is a major underlying disease of progressive pulmonary fibrosis. Therefore, in addition to the radiological features of HP, quantitatively measuring fibrosis is important to evaluate disease severity and progression. The present study aimed to compare three-dimensional computed tomography (3D-CT)-derived lung volumes (LVs) of patients with HP and determine its association with mortality risk.
Methods: In this retrospective and multicenter cohort study, 126 patients diagnosed with HP (fibrotic, n=72 and non-fibrotic, n=54) with a confidence level higher than moderate were enrolled. Each lobe LV was measured using 3D-CT at the time of diagnosis and standardized using predicted forced vital capacity. The 3D-CT LV was compared with those of 42 controls and 140 patients with idiopathic pulmonary fibrosis (IPF).
Results: Compared to patients with fibrotic-HP, the standardized total LV was significantly higher in controls and patients with non-fibrotic-HP and was similar in patients with IPF. Longitudinal analyses demonstrated that approximately half of the patients with fibrotic-HP had an annual decrease in total LV. Decreased total and lower-lobe LVs were associated with shorter survival, and were independently associated with mortality together with ongoing exposure to inciting antigens. A composite model consisting of ongoing exposure to inciting antigens and total or lower-lobe LV successfully classified mortality risk into three groups.
Conclusions: Quantitatively measuring standardized LV can help determine disease severity, progression, and mortality risk in patients with fibrotic-HP.
注記
内容記述 令和6年 浜松医科大学論文賞:優秀論文賞(学生特別枠)
受賞者:矢澤 秀介
ISSN
収録物識別子タイプ PISSN
収録物識別子 1323-8930
EISSN
収録物識別子タイプ EISSN
収録物識別子 1440-1592
NII書誌ID
収録物識別子タイプ NCID
収録物識別子 AA11091750
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 39242341
出版社DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.alit.2024.07.002
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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