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Analysis of Pathogenesis of Autoimmune Insulitis in NOD Mice: Adoptive Transfer Experiments of Insulitis in ILI and NOD Nude Mice
http://hdl.handle.net/10271/2055
http://hdl.handle.net/10271/205567b15c5a-d3a9-46f1-8ab3-4cf53a7957c9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ExpAnim-45_3-233.pdf (1.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2013-08-27 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Analysis of Pathogenesis of Autoimmune Insulitis in NOD Mice: Adoptive Transfer Experiments of Insulitis in ILI and NOD Nude Mice | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | ILI mice | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Insulitis | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Insulitis susceptibility gene | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | NOD mice | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | nude mice | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
Nakamura, Moritaka
× Nakamura, Moritaka
× Nishimura, Masahiko
× Koide, Yukio
× Takato, O.Yoshida
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| 書誌情報 |
Experimental Animals 巻 45, 号 3, p. 233-238, 発行日 1996 |
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| 出版者 | ||||||||||||||
| 出版者 | 日本実験動物学会 | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | © 2003 Japanese Association for Laboratory Animal Science | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | 本文データは学協会の許諾に基づきJ-STAGEから複製したものである | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | In an effort to study the pathophysiological events in the development of insulitis in NOD mice, we have developed ILI- and NOD-nu/nu mice. ILI mice are a nondiabetic inbred strain but are derived from the same Jcl:ICR mouse as NOD mice and share the same H-2 allotype with NOD mice. Splenocytes and CD4+ cells from diabetic NOD mice appeared to transfer insulitis to ILI-nu/nu mice, suggesting that ILI mice already express autoantigen(s) responsible for insulitis. But reciprocal thymic grafts from NOD mice into ILI-nu/nu mice and those from ILI mice into NOD-nu/nu mice failed to allow the development of insulitis, implying that ILI mice possess neither precursor T cells nor the thymic environment responsible for the development of insulitis. In addition, splenocytes from ILI mice appeared to contain regulatory cells which suppress the development of diabetes but not that of insulitis in NOD mice. The use of these nude mice should provide more information on the products of insulitis-susceptibility genes of NOD mice. | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 13411357 | |||||||||||||
| EISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 18817122 | |||||||||||||
| 出版社DOI | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1538/expanim.45.233 | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
