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  1. 学術雑誌論文
  2. 各雑誌掲載論文

A Mutant Mouse with Severe Anemia and Skin Abnormalities Controlled by a New Allele of the Flaky Skin (fsn) Locus

http://hdl.handle.net/10271/2058
http://hdl.handle.net/10271/2058
ca6bd899-db70-4023-bae3-21691b0ba104
名前 / ファイル ライセンス アクション
ExpAnim-54_4-339.pdf ExpAnim-54_4-339.pdf (927.8 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-08-27
タイトル
タイトル A Mutant Mouse with Severe Anemia and Skin Abnormalities Controlled by a New Allele of the Flaky Skin (fsn) Locus
言語
言語 eng
キーワード
主題 anemia
キーワード
主題 dysgenesis
キーワード
主題 flaky skin
キーワード
主題 fsn gene
キーワード
主題 ICR
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Takabayashi, Shuji

× Takabayashi, Shuji

Takabayashi, Shuji

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Katoh, Hideki

× Katoh, Hideki

Katoh, Hideki

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書誌情報 Experimental Animals

巻 54, 号 4, p. 339-347, 発行日 2005-08-11
出版者
出版者 日本実験動物学会
権利
権利情報 © 2005 Japanese Association for Laboratory Animal Science
権利
権利情報 本文データは学協会の許諾に基づきJ-STAGEから複製したものである
抄録
内容記述タイプ Abstract
内容記述 We found a novel recessive mutation in an inbred strain, INT, that was derived from an ICR closed colony. Mice homozygous for this mutation are identified by severe anemia, dysgenesis and neonatal death. This mutation was tentatively named int. Intercrosses of int heterozygotes (+/int) and the flaky skin heterozygotes (+/fsn) resulted in abnormal mice (int/fsn heterozygotes) showing anemia and flaky skin with the expected frequency for autosomal recessive mutation. The int gene was therefore named fsnJic as an allele of the fsn locus on chromosome 17. We carried out phenotype analyses using B6.INT- fsnJic mice to observe phenotypes of blood and skin in the embryonic and neonatal stages. Discrimination of fsnJic embryos from normal embryos was performed by an indirect diagnosis of the fsnJic gene using the D17Mit130 microsatellite marker tightly linked to the fsn locus. The number of fetal nucleated RBC of normal embryos decreased gradually to 17.5 dpc, but that of the abnormal embryos decreased to 14.5 dpc followed by a gradual increase to 17.5 dpc. Skin of fsnJic embryos did not show any abnormalities and expressed cytokeratins normally as skin epithelial cell markers at each embryonic stage (15.5 dpc to 18.5 dpc). Time differences in the appearance of the different phenotypes observed in various tissue and organs of fsn homozygotes suggest they are caused by expression of the fsn gene at different developmental stages.
ISSN
収録物識別子タイプ ISSN
収録物識別子 13411357
EISSN
収録物識別子タイプ ISSN
収録物識別子 18817122
出版社DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1538/expanim.54.339
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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