| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
Phenotype-Based Search of Natural Mutations Related to Hereditary Diseases Existing in a Closed Colony of Mice |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題 |
closed colony |
| キーワード |
|
|
主題 |
hereditary disease |
| キーワード |
|
|
主題 |
ICR |
| キーワード |
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|
主題 |
mouse |
| キーワード |
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|
主題 |
natural mutation |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Katoh, Hideki
Nishikawa, Tetsu
Kimura, Jiro
Yamauchi, Yumika
Takabayashi, Shuji
|
| 書誌情報 |
Experimental Animals
巻 59,
号 2,
p. 183-190,
発行日 2010-05-19
|
| 出版者 |
|
|
出版者 |
日本実験動物学会 |
| 権利 |
|
|
権利情報 |
© 2010 Japanese Association for Laboratory Animal Science |
| 権利 |
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|
権利情報 |
本文データは学協会の許諾に基づきJ-STAGEから複製したものである |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
We attempted to detect natural mutations existing in the Jcl:ICR closed colony of mice which is maintained by random mating. We used ordinary genetic backcrosses to efficiently detect recessive mutations carried by individual mice in the colony. Crosses of DBA/2 females and ICR males were performed to obtain F1 mice. Four F1 females randomly selected from each cross were backcrossed to the male parent. More than thirty backcross progeny were obtained from each F1 female by several deliveries. Phenotypes of the backcross progeny were observed macroscopically at about one month of age. As a result, 18 (26.1%) of 69 Jcl:ICR males carried 11 recessive mutation(s). Based on the phenotypes, the tentative names were abnormal kidney, aplasia of eyelids/hind limb digits, circling, dwarfism, heterotaxy, hind limb paralysis, hydrocephalus, rigidity (or rigor), testicular hypoplasia, tremor, and wobbling. The genes responsible for aplasia of eyelids/hind limb digits and dwarfism were each carried by two males, the genes responsible for hydrocephalus and testicular hypoplasia were each carried by three males and the gene responsible for wobbling by four males. It was strongly suggested that the genes shared by several males originated from an identical mutated gene. Surprisingly, male No. 43 had the responsible genes of abnormal kidneys and testicular hypoplasia, and No. 79 had those of dwarfism and tremor. The results obtained in this study suggest that breeders need to be aware of the presence of natural mutations in their colonies. |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13411357 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
18817122 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1538/expanim.59.183 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ExpAnim-59_2-183.pdf (738.6 kB)
