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  1. 学術雑誌論文
  2. 各雑誌掲載論文

Phenotype-Based Search of Natural Mutations Related to Hereditary Diseases Existing in a Closed Colony of Mice

http://hdl.handle.net/10271/2060
http://hdl.handle.net/10271/2060
fb803532-4f1d-419b-a48b-c5554fab8a08
名前 / ファイル ライセンス アクション
ExpAnim-59_2-183.pdf ExpAnim-59_2-183.pdf (738.6 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-08-27
タイトル
タイトル Phenotype-Based Search of Natural Mutations Related to Hereditary Diseases Existing in a Closed Colony of Mice
言語
言語 eng
キーワード
主題 closed colony
キーワード
主題 hereditary disease
キーワード
主題 ICR
キーワード
主題 mouse
キーワード
主題 natural mutation
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Katoh, Hideki

× Katoh, Hideki

Katoh, Hideki

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Nishikawa, Tetsu

× Nishikawa, Tetsu

Nishikawa, Tetsu

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Kimura, Jiro

× Kimura, Jiro

Kimura, Jiro

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Yamauchi, Yumika

× Yamauchi, Yumika

Yamauchi, Yumika

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Takabayashi, Shuji

× Takabayashi, Shuji

Takabayashi, Shuji

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書誌情報 Experimental Animals

巻 59, 号 2, p. 183-190, 発行日 2010-05-19
出版者
出版者 日本実験動物学会
権利
権利情報 © 2010 Japanese Association for Laboratory Animal Science
権利
権利情報 本文データは学協会の許諾に基づきJ-STAGEから複製したものである
抄録
内容記述タイプ Abstract
内容記述 We attempted to detect natural mutations existing in the Jcl:ICR closed colony of mice which is maintained by random mating. We used ordinary genetic backcrosses to efficiently detect recessive mutations carried by individual mice in the colony. Crosses of DBA/2 females and ICR males were performed to obtain F1 mice. Four F1 females randomly selected from each cross were backcrossed to the male parent. More than thirty backcross progeny were obtained from each F1 female by several deliveries. Phenotypes of the backcross progeny were observed macroscopically at about one month of age. As a result, 18 (26.1%) of 69 Jcl:ICR males carried 11 recessive mutation(s). Based on the phenotypes, the tentative names were abnormal kidney, aplasia of eyelids/hind limb digits, circling, dwarfism, heterotaxy, hind limb paralysis, hydrocephalus, rigidity (or rigor), testicular hypoplasia, tremor, and wobbling. The genes responsible for aplasia of eyelids/hind limb digits and dwarfism were each carried by two males, the genes responsible for hydrocephalus and testicular hypoplasia were each carried by three males and the gene responsible for wobbling by four males. It was strongly suggested that the genes shared by several males originated from an identical mutated gene. Surprisingly, male No. 43 had the responsible genes of abnormal kidneys and testicular hypoplasia, and No. 79 had those of dwarfism and tremor. The results obtained in this study suggest that breeders need to be aware of the presence of natural mutations in their colonies.
ISSN
収録物識別子タイプ ISSN
収録物識別子 13411357
EISSN
収録物識別子タイプ ISSN
収録物識別子 18817122
出版社DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1538/expanim.59.183
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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