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  1. 学術雑誌論文
  2. 各雑誌掲載論文

Effects of Inspiratory Oxygen Concentration and Ventilation Method on a Model of Hemorrhagic Shock in Rats

http://hdl.handle.net/10271/2061
http://hdl.handle.net/10271/2061
451a285d-fd21-4181-a4b3-14a10d59f87c
名前 / ファイル ライセンス アクション
ExpAnim-51_5-477.pdf ExpAnim-51_5-477.pdf (505.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-08-27
タイトル
タイトル Effects of Inspiratory Oxygen Concentration and Ventilation Method on a Model of Hemorrhagic Shock in Rats
言語
言語 eng
キーワード
主題 hemorrhagic shock
キーワード
主題 oxygen concentration
キーワード
主題 rat
キーワード
主題 ventilation method
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Suzuki, Akira

× Suzuki, Akira

Suzuki, Akira

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Iwamoto, Tatsuaki

× Iwamoto, Tatsuaki

Iwamoto, Tatsuaki

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Sato, Shigehito

× Sato, Shigehito

Sato, Shigehito

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書誌情報 Experimental Animals

巻 51, 号 5, p. 477-483, 発行日 2003-03-28
出版者
出版者 日本実験動物学会
権利
権利情報 © 2003 Japanese Association for Laboratory Animal Science
権利
権利情報 本文データは学協会の許諾に基づきJ-STAGEから複製したものである
抄録
内容記述タイプ Abstract
内容記述 The effect of inspiratory oxygen concentration and the ventilation method on hemorrhagic shock was investigated. Twenty-eight rats were divided into four groups: mechanical ventilation with pure oxygen (M100); mechanical ventilation with air (M21); spontaneous respiration with pure oxygen (S100); and spontaneous respiration with air (S21). Under intravenous pentobarbital anesthesia, hemorrhagic shock (HS) was induced by withdrawal of blood from the femoral artery. Mean arterial blood pressure (MAP) was maintained at 40-50 mmHg for 2 h. After HS, the blood remaining in the reservoir was reinfused. Then survival rate and MAP were monitored for 2 h. Blood samples were withdrawn and vascular reactivity to norepinephrine (NE; 3.0 μg/kg) was tested before and after HS. Results were shown by changes in MAP in response to NE. During HS, the survival rate of the S21 group was lower than that of the M100 and S100 groups (p<.05). Before HS, MAPs of M100 and S100 groups were significantly higher than those of M21 and S21 groups (p<.05). In the M100 and M21 groups, MAPs at 2 h after reinfusion were significantly lower than the baseline value (p<.05). Before HS, reactivity to NE of the M21 group was significantly higher than that of the other groups (p<.05). In the M21 group, reactivity to NE after HS was significantly lower than it was before HS (p<.05). Inspiratory oxygen concentration and the ventilation method affect the survival rate and vascular reactivity of the rat hemorrhagic shock model. Selection of the inspiratory oxygen concentration and the ventilation method should be made according to the purpose of the individual experiment.
ISSN
収録物識別子タイプ ISSN
収録物識別子 13411357
EISSN
収録物識別子タイプ ISSN
収録物識別子 18817122
出版社DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1538/expanim.51.477
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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