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Intracranial Self-Stimulation Induces Fos Expression in GABAergic Neurons in the Rat Mesopontine Tegmentum
http://hdl.handle.net/10271/2064
http://hdl.handle.net/10271/20642b46af15-4b35-46c6-b0fd-b0d8f9bde356
| 名前 / ファイル | ライセンス | アクション |
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Neuroscience-106_3-633.pdf (469.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2013-08-27 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Intracranial Self-Stimulation Induces Fos Expression in GABAergic Neurons in the Rat Mesopontine Tegmentum | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | intracranial self-stimulation | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | microdialysis | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Fos | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | acetylcholine | |||||||||||||
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| 主題 | choline acetyltransferase | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | GABA | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
Ishida, Y
× Ishida, Y
× Nakamura, M
× Furuno, N
× Nishimori, T
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| 書誌情報 |
Neuroscience 巻 106, 号 3, p. 633-641, 発行日 2001-09-27 |
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| 出版者 | ||||||||||||||
| 出版者 | Elsevier Science | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | © 2001 IBRO. Published by Elsevier Science Ltd. | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | The cholinergic neurons which originate in the mesopontine tegmentum and innervate the midbrain ventral tegmental area have been proposed to play a key role in intracranial self-stimulation reward. This mesopontine area also contains GABA neurons. Detailed information is still lacking, however, about the relationship of cholinergic and GABAergic neurons in this region to self-stimulation reward. Therefore, using double immunostaining for Fos as a marker of neuronal activity and choline acetyltransferase as a marker of cholinergic neurons, or for Fos and GABA, we investigated whether self-stimulation of the medial forebrain bundle induces Fos expression within cholinergic and GABAergic neurons in two regions of the mesopontine tegmentum, i.e., pedunculopontine tegmental nucleus and laterodorsal tegmental nucleus. Self-stimulation of the medial forebrain bundle for one hour induced a large increase in the number of cells expressing Fos in both the pedunculopontine tegmental nucleus and laterodorsal tegmental nucleus, when compared to control brains. However, the self-stimulation-induced expression of Fos was restricted mostly to GABA-, but not choline acetyltransferase-, immunostained cells. We also examined, using microdialysis, whether self-stimulation increases acetylcholine efflux in the ventral tegmental area, a terminal region of the mesopontine tegmentum cholinergic pathway. One hour of self-stimulation significantly increased acetylcholine efflux from this terminal area. The results indicate that intracranial self-stimulation of the medial forebrain bundle may increase acetylcholine release without affecting expression of Fos in cholinergic neurons, while the same stimulation may induce Fos expression in GABAergic neurons of the mesopontine tegmentum. GABAergic as well as cholinergic neurons in this area appear to be activated by self-stimulation reward in the medial forebrain bundle. | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 03064522 | |||||||||||||
| 出版社DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1016/S0306-4522(01)00298-6 | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
