| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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タイトル |
Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouse |
| 言語 |
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言語 |
eng |
| キーワード |
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|
主題 |
circadian rhythm |
| キーワード |
|
|
主題 |
locomotor activity |
| キーワード |
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|
主題 |
microdialysis |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
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その他のタイトル |
生存ＣＢＡマウスにおける松果腺からのメラトニンの２相性概日分泌 |
| 著者 |
Nakamura, Masato
Iigo, Masayuki
Okamura, Hitoshi
|
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America
巻 100,
号 16,
p. 9584-9589,
発行日 2003-08-05
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| 出版者 |
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出版者 |
National Academy of Sciences |
| 権利 |
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|
権利情報 |
© 2003 The National Academy of Sciences |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Circadian melatonin secretion is the best-known output signal from the circadian pacemaker in the suprachiasmatic nucleus that indicates internal conditions of the body. We have established a system that enables long-term monitoring of melatonin secretion by implanting a transverse microdialysis probe in or near the pineal gland in a freely moving mouse. This in vivo method enabled continuous measurement of melatonin secretion over a period of >20 days in individual CBA mice, with simultaneous recording of the locomotor activity. Pineal melatonin secretion was completely matched to the circadian change of locomotor activity, and for the light-induced phase shift, the shift of melatonin secretion was clearer than the shift of locomotor rhythm. This analysis allowed us to detect rhythm with a high sensitivity: two peaks of daily secretion were observed, with the first small peak at the day-night transition time and the second large peak at midnight. The large nighttime peak was suppressed by tetrodotoxin, a Na+ channel blocker, and enhanced by both phenylephrine and isoproterenol, α- and β-adrenergic agonists, whereas daytime melatonin levels were not affected by tetrodotoxin infusion. This finding suggests that, in CBA mice, melatonin release at night is activated by adrenergic signaling from the superior cervical ganglion, but the enhancement of melatonin during daytime is not mediated by neuronal signaling. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00278424 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
10916490 |
| PubMed番号 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
PMID |
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関連識別子 |
12874384 |
| 出版社DOI |
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|
関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1073/pnas.1631069100 |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
ProcNatlAcadSci100_16-9584.pdf (1.6 MB)
