| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Trans-Serosal Leakage of Proinflammatory Mediators during Abdominal Aortic Aneurysm Repair: Role of Phospholipase A2in Activating Leukocytes |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
gut barrier function |
| キーワード |
|
|
主題 |
abdominal aortic aneurysm |
| キーワード |
|
|
主題 |
permeability |
| キーワード |
|
|
主題 |
peritoneum |
| キーワード |
|
|
主題 |
phospholipase A2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sagara, Daisuke
Unno, Naoki
Yamamoto, Naoto
Suzuki, Minoru
Nishiyama, Motohiro
Tanaka, Hiroki
Konno, Hiroyuki
Mitsuoka, Hiroshi
|
| 書誌情報 |
en : Annals of Vascular Diseases
巻 3,
号 2,
p. 131-139,
発行日 2010-08-24
|
| 出版者 |
|
|
出版者 |
Japanese College of Angiology, The Japanese Society for Vascular Surgery, Japanese Society of Phlebology |
|
言語 |
en |
| 権利 |
|
|
権利情報 |
Copyright 2010 Japanese College of Angiology, The Japanese Society for Vascular Surgery, Japanese Society of Phlebology |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJ-stageから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Gut barrier failure and the resultant translocation of luminal bacteria and bacterial products into the systemic circulation have been proposed as pathogenic mechanisms of multiorgan dysfunction syndrome (MODS) in open repair of abdominal aortic aneurysm (AAA). Our study aimed to demonstrate the direct release of gut-derived inflammatory mediators via the trans-serosal route in humans. Fifteen patients who underwent elective infrarenal open repair of AAA were randomized into two groups. In Group I patients (n = 10), the small intestine was exteriorized into a bowel bag. In Group II patients (n = 5), the small intestine was packed within the peritoneal cavity using large gauzes. We collected the bowel bag fluid in Group I and the ascites fluid, squeezed out from the gauzes at the end of surgery, in Group II. Leukocytes were collected from patients’ blood samples. Incubation with the bowel bag fluid and ascites fluid caused a significant increase in both granulocyte pseudopod formation and CD11b expression compared to that with control fluid (p < 0.01). The addition of phospholipase A2 (PLA2) inhibitor quinacrine abolished leukocyte activation by the bowel bag fluid. Based on these results, we consider that trasns-serosal leakage of gut-derived mediators occurred during the open repair of AAA; further, sPLA2 may be the most potent mediator in the activation of leukocytes among such gut-derived mediators in AAA surgery. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1881641X |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18816428 |
| 出版社DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3400/avd.oa00930 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
AnnVascDis3_2-131.pdf (287.0 kB)
