| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
EFFECTS OF PROPRANOLOL AND DILTIAZEM ON CARNITINE DERIVATIVES AND ACYL CoA IN ISCHEMIC MYOCARDIUM |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Acute myocardial ischemia |
| キーワード |
|
|
主題 |
Carnitine derivatives |
| キーワード |
|
|
主題 |
Long chain acyl CoA |
| キーワード |
|
|
主題 |
Propranolol |
| キーワード |
|
|
主題 |
Diltiazem |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
KAMIYA, Jun
KOBAYASHI, Akira
YAMAZAKI, Noboru
|
| 書誌情報 |
Japanese circulation journal
巻 49,
号 11,
p. 1167-1174,
発行日 1985-11-20
|
| 出版者 |
|
|
出版者 |
日本循環器学会 |
| 権利 |
|
|
権利情報 |
Copyright 日本循環器学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきCiNiiから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The accumulation of intermediates subsequent to impaired β-oxidation of free fatty acid (FFA) has been suggested as a cause of cellular damage in ischemic myocardium. ^<1-2> We investigated the effects of propranolol and diltiazem on carnitine metabolism in ischemic myocardium. Propranolol (0.2 mg/kg/min, i.v.) and diltiazem (0.1 mg/kg/min, i.v.) were administered for 5 min, the administration started 10 min before coronary occlusion. ECGs were continuously recorded throughout the experiment. Myocardial samples were prepared from both the non-ischemic and ischemic areas 40 min after coronary ligation. Adenosine triphosphate (ATP), free carnitine, long chain acyl carnitine and long chain acyl CoA were assayed. Propranolol reduced the decrease of ATP and the accumulation of long chain acyl CoA, induced by myocardial ischemia. Diltiazem reduced the decrease of ATP and free carnitine, and the accumulation of long chain acyl carnitine in the ischemic area. Propranolol and diltiazem significantly reduced the grade of ventricular arrhythmia. These results suggest that the protective mechanisms of propranolol and diltiazem on myocardium are based, at least in part, on their beneficial effects upon myocardial carnitine metabolism |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00471828 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1253/jcj.49.1167 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
CircJ49_11-1167.pdf (647.4 kB)
