| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Pharmacokinetics of FK027 (Cefixime) in Healthy Volunteers after Intravenous Injection |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
FK027 |
| キーワード |
|
|
主題 |
cefixime |
| キーワード |
|
|
主題 |
pharmacokinetic parameters |
| キーワード |
|
|
主題 |
serum concentration |
| キーワード |
|
|
主題 |
probenecid |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Nakashima, Mitsuyoshi
Kanamaru, Mitsutaka
Noguchi, Hideyo
Kajiho, Tokuaki
|
| 書誌情報 |
臨床薬理
巻 17,
号 3,
p. 559-568,
発行日 1986-09-25
|
| 出版者 |
|
|
出版者 |
日本臨床薬理学会 |
| 権利 |
|
|
権利情報 |
Copyright 日本臨床薬理学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJournal archiveから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The pharmacokinetics of FK027 was investigated in 6 healthy male volunteers after intravenous injection of 100mg both without and with oral probenecid 1g by a two-way crossover design. The serum concentrations of FK027 without probenecid declined biphasically. The distribution half-life (t1/2α) was 0.148±0.015hr and the elimination half-life (t1/2β) was 2.519±0.070hr. The volume of distribution of the central compartment (Vc) was 4.032±0.379 L and the volume of distribution of the peripheral compartment (Vt) was 7.074±0.576 L. The total body clearance (Clbody) was 58.59±4.63ml/min and the renal clearance (Clr) was 37.40±1.82ml/min. The unchanged drug excreted in the 24-hr urine was 64.8±3.5%. When FK027 was given with probenecid, the serum concentrations and area under the concentration-time curve (AUC) increased significantly and t1/2β and the volume of distribution at steady state (Vdss) increased slightly, but Clbody and Clr decreased. These results indicate that FK027 is rapidly distributed to the tissues and thereafter gradually eliminated from the body, and it is excreted from the kidneys, mainly through glomerular filtration and to some extent through renal tubular secretion. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03881601 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18828272 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JJClinPharTher17_3-559.pdf (1.1 MB)
