| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Noninvasive Evaluation of Cardiovascular Effects of β-Adrenergic Blockers with Different Pharmacological Properties |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
β-blockers |
| キーワード |
|
|
主題 |
cardiovascular effect |
| キーワード |
|
|
主題 |
systolic time intervals |
| キーワード |
|
|
主題 |
echocardiography |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Ohguchi, Sadao
Nakashima, Mitsuyoshi
Hashimoto, Hisakuni
Takiguchi, Yoshiharu
Oguro, Katsunori
|
| 書誌情報 |
臨床薬理
巻 15,
号 4,
p. 525-534,
発行日 1984-12-30
|
| 出版者 |
|
|
出版者 |
日本臨床薬理学会 |
| 権利 |
|
|
権利情報 |
Copyright 日本臨床薬理学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJournal archiveから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The effects of nadolol (Nad), indenolol (Idn), metoprolol (Met), pindolol (Pid), arotinolol (Art, S-596), and propranolol (Prp) on the cardiovascular system were studied noninvasively in healthy male volunteers. Exercise testing. with a bicycle ergometer was performed both before and after single oral administration of these β-blockers, and any changes in the exercise induced increase in heart rate systolic blood pressure product (ΔDP) were studied. Systolic time intervals were measured from the simultaneous recording of carotid pulse, phonocardiogram, and electrocardiogram at rest. Left ventricular dimensions were measured by echocardiography, and ejection fraction (EF), stroke index (SI), and cardiac index (CI) were calculated by the standard techniques. Systemic vascular resistance (SVR) was computed from these data. ΔDP was decreased with all β-blockers. According to the degree of this effect, the relative potency of these drugs was estimated to be as follows: Pid > Art> Idn≒Prp> Nad ≒ Met. The ratio of pre-ejection period to left ventricular ejection time was increased with all β-blockers. EF, SI, and CI were decreased by all β-blockers except Pid, by which SI and CI were kept almost unchanged, and EF was significantly increased. Therefore, Pid was thought to be less cardiosuppressive than the other β-blockers. SVR was significantly decreased by Pid, while it was increased by all the other β-blockers. These results suggest that the acute hemodynamic response to β-blockers is determined primarily by the property of intrinsic sympathomimetic activity. Neither β1-selectivity nor membrane stabilizing effect was shown to be a major factor modifying the central or peripheral hemodynamic response to β-blockers. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03881601 |
| EISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18828272 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JJClinPharTher15_4-525.pdf (1.1 MB)
