| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Photosensitizer-Induced Lipid Peroxidation in Retinal Homogenates under Illumination |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
photosensitizers |
| キーワード |
|
|
主題 |
lipid peroxidation |
| キーワード |
|
|
主題 |
retina |
| キーワード |
|
|
主題 |
α-tocopherol |
| キーワード |
|
|
主題 |
superoxide dismutase |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Hiramitsu, Tadahisa
Miura, Yoshifumi
Machida, Hiroyuki
|
| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition
巻 12,
号 2,
p. 109-114,
発行日 1992-08
|
| 出版者 |
|
|
出版者 |
日本酸化ストレス学会 |
| 権利 |
|
|
権利情報 |
Copyright JCBN誌編集事務局 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
In this study, the effect of photosensitizers on lipid peroxidation in the retina was investigated. Porcine retinal homogenate was exposed to illumination from a fluorescent lamp with or without photosensitizers such as hematoporphyrin, rose bengal, and fluorescein for 60min. The control, which was exposed to illumination without photosensitizers, did not show a significant increase in lipid peroxidation. However, lipid peroxidation in the homogenates exposed to illumination with photosensitizers increased significantly and in a dose-dependent manner. For concentrations of more than 100μM of all three photosensitizers, lipid peroxidation in the retina homogenates increased to a level approximately 2-3 times higher than that in the sample before illumination, and to a level 10 times higher than that of the control. α-Tocopherol inhibited hematoporphyrin-induced lipid peroxidation in a dose-dependent manner, but superoxide dismutase did not show an inhibitory effect. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09120009 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18805086 |
| 出版社DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3164/jcbn.12.109 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JClinBiochemNutr12-109.pdf (607.6 kB)
