| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Comparison of Class II and Class III Activity of dl-Sotalol in Healthy Volunteers |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Sotalol |
| キーワード |
|
|
主題 |
Pharmacodynamics |
| キーワード |
|
|
主題 |
β adrenergic blocker |
| キーワード |
|
|
主題 |
Heart rate variability |
| キーワード |
|
|
主題 |
Potassium channel blocker |
| キーワード |
|
|
主題 |
Spectral analysis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
KIMURA, Masahiko
UMEMURA, Kazuo
KOSUGE, Kazuhiro
NISHIMOTO, Masahiko
OHASHI, Kyoichi
NAKASHIMA, Mitsuyosi
IKEDA, Yasuhiro
|
| 書誌情報 |
Japanese Heart Journal
巻 39,
号 1,
p. 79-86,
発行日 1997-06
|
| 出版者 |
|
|
出版者 |
International Heart Journal Association |
| 権利 |
|
|
権利情報 |
Copyright International Heart Journal Association |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Racemic sotalol has demonstrated anti-arrhythmic properties which include Class II (β blockade) and Class III (potassium channel blockade) activity. The Class II activity is demonstrated primarily in l-sotalol, and Class III activity is almost equipotent in each isomer. Class II and Class III activity of dl-sotalol was investigated following repeated oral administration (80mg b. i. d.) for 7 days. Class II activity was evaluated according to the low frequency spectral power obtained by fast Fourier analysis of the R-R interval variation. Class III activity was evaluated according to the change in the QTc interval of the surface electrocardiogram. The low frequency spectral power decreased after administration of the first dose on day 1 and this trend continued throughout the duration of the study. The QTc interval did not change with dl-sotalol administration. These findings may suggest that Class II activity is more potent than Class III activity. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00214868 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1348673X |
| 出版社DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1536/ihj.39.79 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JHeartJ39_1-79.pdf (359.5 kB)
