| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Effects of Procainamide and Disopyramide on Long Chain Acyl Carnitine and Long Chain Acyl CoA Concentrations in the Ischemic Heart |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Free fatty acids |
| キーワード |
|
|
主題 |
Ventricular arrhythmias |
| キーワード |
|
|
主題 |
Antiarrhythmic drugs |
| キーワード |
|
|
主題 |
Antiarrhythmic mechanism |
| キーワード |
|
|
主題 |
Cyclic AMP |
| キーワード |
|
|
主題 |
Carnitine |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kobayashi, Akira
Watanabe, Hiroshi
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Heart Journal
巻 29,
号 6,
p. 831-840,
発行日 1987-05-27
|
| 出版者 |
|
|
出版者 |
International Heart Journal Association |
| 権利 |
|
|
権利情報 |
by International Heart Journal Association |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Though the efficacies of procainamide and disopyramide in treating arrhythmias are well established, their precise mechanisms of antiarrhythmic action remain unclear. Arrhythmias which occur during acute myocardial ischemia can be explained partly on a metabolic basis. The accumulation of intermediates subsequent to impaired β-oxidation of free fatty acids has been suggested as a cause of serious arrhythmias. The purpose of this study was to investigate changes in free carnitine, long chain acyl carnitine and long chain acyl CoA concentrations in the ischemic canine heart following the administration of procainamide and disopyramide. The coronary artery was occluded for 40min and myocardial samples were prepared from both nonischemic and ischemic areas. Procainamide and disopyramide prevented the accumulation of long chain acyl carnitine and long chain acyl CoA in the ischemic myocardium. The results showed that procainamide and disopyramide had beneficial effects on fatty acid metabolism. It was suggested that one of the antiarrhythmic mechanisms of these drugs might be the prevention of the accumulation of fatty acyl derivatives in the isehemic myocardium. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00214868 |
| EISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1348673X |
| 出版社DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1536/ihj.29.831 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JHeartJ-29-381.pdf (542.8 kB)
