| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
Changes in the Subcellular Distribution of Free Carnitine and Its Acyl Derivatives in Diabetic Rat Hearts Following Treatment with L-Carnitine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Free carnitine |
| キーワード |
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|
主題 |
Long-chain acylcarnitine |
| キーワード |
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|
主題 |
Cellular distribution |
| キーワード |
|
|
主題 |
Mitochondria |
| キーワード |
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|
主題 |
Diabetic heart |
| キーワード |
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|
主題 |
L-carnitine treatment |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Aoshima, Shigeyuki
Fujisawa, Shigeki
Kobayashi, Akira
|
| 書誌情報 |
Japanese Heart Journal
巻 34,
号 6,
p. 763-772,
発行日 1993-05-10
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| 出版者 |
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出版者 |
International Heart Journal Association |
| 権利 |
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|
権利情報 |
by International Heart Journal Association |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Carnitine deficiency has been demonstrated in diabetic hearts, and it is also well known that L-carnitine administration has a beneficial effect on cardiac function. Carnitine treatment would be expected to reduce the accumulation of long-chain acylcarnitine. However, many reports have shown that myocardial long-chain acylcarnitine levels were increased following treatment with L-carnitine in whole-heart studies. Since acylcarnitine exists in both the mitochondrial and cytosolic compartments, it is difficult to investigate changes in subcellular distribution by studying whole-heart preparations. The present study investigated the myocardial subcellular distribution of carnitine and its acyl derivatives in diabetic rats with or without L-carnitine treatment. Approximately 90% of total cellular carnitine was located in the cytosol in the diabetic hearts. Both mitochondrial and cytosolic levels of free carnitine and short-chain acylcarnitine were significantly decreased in the diabetic heart. However, the mitochondrial level of long-chain acylcarnitine was significantly increased. Lcarnitine treatment reduced the mitochondrial level of long-chain acylcarnitine, but the cytosolic level of long-chain acylcarnitine was significantly increased. These results show that L-carnitine treatment prevents the accumulation of long-chain acylcarnitine in the mitochondrial space and then reduces the detergent effect of long-chain acylcarnitine on the mitochondrial membrane. We suggest that it is a possible mechanism of the beneficial effect of L-carnitine treatment on the diabetic heart. (Jpn Heart J 34: 763-772, 1993) |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00214868 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1348673X |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1536/ihj.34.763 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JHeartJ-34-763.pdf (661.2 kB)
