| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
Effect of L-Carnitine on the Cellular Distribution of Carnitine and Its Acyl Derivatives in the Ischemic Heart |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Cellular distribution of carnitine |
| キーワード |
|
|
主題 |
Ischemic myocardium |
| キーワード |
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|
主題 |
Cytosolic compartment |
| キーワード |
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|
主題 |
Mitochondrial compartment |
| キーワード |
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|
主題 |
Long-chain acylcarnitine |
| キーワード |
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主題 |
L-carnitine treatment |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Fujisawa, Shigeki
Kobayashi, Akira
Hironaka, Yutaka
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Heart Journal
巻 33,
号 5,
p. 693-705,
発行日 1992-01-07
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| 出版者 |
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出版者 |
International Heart Journal Association |
| 権利 |
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|
権利情報 |
by International Heart Journal Association |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The purpose of this study was to investigate the cellular distribution of carnitine and its acyl derivatives in the normal and ischemic myocardium, and the effects of exogenous l-carnitine on this distribution and mitochondrial function in the ischemic dog heart. Under nonischemic conditions, about 93% of the total cellular carnitine was located in the cytosolic compartment and 6.5% in the mitochondrial compartment. Sixty minutes of ischemia induced a decrease in the cytosolic free carnitine content, but caused the accumulation of long-chain acylcarnitine in the cytosolic and mitochondrial compartments. Treatment with l-carnitine (30 or 100mg/kg, i.v.) inhibited the mitochondrial accumulation of long-chain acylcarnitine. Free fatty acid (FFA) metabolism in the mitochondria differs from that in the cytosol. So, it is necessary to investigate the changes in FFA metabolism in both of these cellular compartments. Our results suggest that l-carnitine has a protective effect on the ischemic heart by selectively reducing mitochondrial accumulation of long-chain acylcarnitine. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00214868 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1348673X |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1536/ihj.33.693 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JHeartJ-33-693.pdf (706.8 kB)
