| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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タイトル |
Effect of Nitroglycerin on the Free Radical Formation of Myocardial Mitochondria Impaired by Ethanol |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
主題 |
Respiratory control ratio |
| キーワード |
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|
主題 |
Free radical concentrations in state 4 respiration |
| キーワード |
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主題 |
The ratio of free radical concentrations in state 4 to state 1 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Suzuki, Yoshikazu
Kamikawa, Tadashi
Yamamoto, Mitate
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Heart Journal
巻 22,
号 4,
p. 627-635,
発行日 1980-09-04
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| 出版者 |
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出版者 |
International Heart Journal Association |
| 権利 |
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|
権利情報 |
by International Heart Journal Association |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
In order to investigate the direct metabolic effect of nitroglycerin on myocardium, its effect on mitochondrial free radical formation was studied in vitro, using the dog heart mitochondria impaired by ethanol. Free radical concentrations in state 4 respiration or the ratio of free radical concentrations in state 4 to state 1 was used as an index of mitochondrial function. Free radical concentrations were represented as ESR intensity. In normal control, ESR intensity increased from 0.115±0.030 (mean ±SD) per mg protein in state 1 to 0.178±0.017 in state 4 (p<0.001). When mitochondria were treated with 10-4M ethanol, on the other hand, ESR intensity decreased from 0.163±0.34 in state 1 to 0.137±0.019 in state 4 (p<0.05). When mitochondria were treated with 10-6M nitroglycerin, in spite of the presence of 10-4M ethanol, ESR intensity increased from 0.124±0.23 in state 1 to 0.153±0.024 in state 4 (p<0.05). ESR intensity in state 1 was increased by the treatment of ethanol (p<0.05), whereas ESR intensity in state 4 was decreased (p<0.001), and these effects were prevented by nitroglycerin (p<0.05). The ratio of ESR intensity in state 4 to state 1 demonstrated more remarkably the effects of ethanol and nitroglycerin. Ethanol reduced the ratio from 1.65±0.47 in the control to 0.86±0.13 (p<0.001) and the reduction was prevented by nitroglycerin to 1.25±0.23 (p<0.01). It is concluded that nitroglycerin prevented the impairment of free radical formation of the mitochondria induced by ethanol, presumably by a mitochondrial membrane-stabilizing action. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00214868 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1348673X |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1536/ihj.22.627 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JHeartJ-22-627.pdf (520.9 kB)
