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Better-Surviving Liver Grafts by the Injection of Anti-CD2 Antibody: The Important Roles of Host CD8+ and CD2+CD28+ T Cells in Chronic Graft Rejection and β Type Platelet-Derived Growth Factor Receptor (PDGFR-β) Expression on Apoptotic Liver Grafts
http://hdl.handle.net/10271/2488
http://hdl.handle.net/10271/248843e84f5e-58f8-42fc-8f2a-e885a91531d6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Tohoku Journal-187-215.pdf (1.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2013-08-27 | |||||||
| タイトル | ||||||||
| タイトル | Better-Surviving Liver Grafts by the Injection of Anti-CD2 Antibody: The Important Roles of Host CD8+ and CD2+CD28+ T Cells in Chronic Graft Rejection and β Type Platelet-Derived Growth Factor Receptor (PDGFR-β) Expression on Apoptotic Liver Grafts | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | anti-CD2 Mab | |||||||
| キーワード | ||||||||
| 主題 | anti-PDGFR-β | |||||||
| キーワード | ||||||||
| 主題 | splenectomy | |||||||
| キーワード | ||||||||
| 主題 | liver graft | |||||||
| キーワード | ||||||||
| 主題 | apoptosis | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
Nakatsuji, Tadako
× Nakatsuji, Tadako
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| 書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 187, 号 3, p. 215-225, 発行日 1999-02-12 |
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| 出版者 | ||||||||
| 出版者 | 東北ジャーナル刊行会 | |||||||
| 権利 | ||||||||
| 権利情報 | Copyright 2005 Tohoku University Medical Press | |||||||
| 権利 | ||||||||
| 権利情報 | 本文データは学協会の許諾に基づきJ-STAGEから複製したものである | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Syngeneic liver grafts were implanted in the livers of 22 LEW/Sea strain rats. To prolong the graft survival, anti-CD2 monoclonal antibody (MAb) or anti β type platelet-derived growth factor receptor (PDGFR-β) antibody (Ab) was injected, or splenectomy was performed in the rats which were then followed until 10 to 11 weeks posttransplantation. The 22 rats with chronic graft rejection showed increased CD8a-like antigen (probably Fas ligand) on the peripheral blood T cells. All the liver grafts had both necrosis and apoptosis. The liver graft apoptosis was indicated by histopathological abnormalities, and by DNA strand breaks and hemosiderin depositions in the cytoplasm. PDGFR-β expression in the apoptotic liver graft was demonstrated immunohistochemically. Among the 17 rats injected with anti-CD2 MAb, CD2 signaling on host T cells was effectively suppressed by the injection of anti-CD2 MAb in 4 rats with better-surviving liver grafts. In these 4 rats, CD28 antigen on thymic lymphocytes was down-modulated and high numbers (136-233-positive cells per lobe) of the epithelial reticular cells with apoptotic lymphocytes were counted. Anti-PDGFR-β Ab caused high pulmonary secretions of growth factors and reticular fibrosis in the lungs of 5 rats injected with the Ab. Anti-PDGFR-β Ab injection reduced the host cell apoptosis in the lung and thymus, but did not prolong the survival of liver grafts. In the 9 rats with both splenectomy and anti-CD2 MAb injection, pulmonary apoptosis was induced with the 6-16% reductions of CD4+ lymphocytes. Prolonged graft survival was observed in only one of the 9 rats. Anti-CD2 MAb was effective for prolonging the liver graft survival with suppressed CD28 antigen, but anti-PDGFR-β Ab and splenectomy were not. | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 00408727 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 13493329 | |||||||
| 出版社DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1620/tjem.187.215 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
