| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
DUAL-TRACER AUTORADIOGRAPHY WITH THALLIUM-201 AND IODINE-125 MIBG IN BIO 14.6 CARDIOMYOPATHIC SYRIAN HAMSTERS |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Cardiomyopathy |
| キーワード |
|
|
主題 |
Sympathetic innervation |
| キーワード |
|
|
主題 |
Autoradiography |
| キーワード |
|
|
主題 |
MIBG |
| キーワード |
|
|
主題 |
201Ti |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Taguchi, Takahisa
Kobayashi, Akira
Kurata, Chinori
Tawarahara, Kei
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Circulation Journal
巻 57,
号 11,
p. 1089-1096,
発行日 1992-09-16
|
| 出版者 |
|
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出版者 |
日本循環器学会 |
| 権利 |
|
|
権利情報 |
Copyright日本循環器学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJournal Archiveから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Dual-tracer imaging of the heart with 125I-metaiodobenzylguanicline (MIBG) and 201Tl can simultaneously demonstrate the distribution of sympathetic nerve endings and the underlying myocardial perfusion. A quantitative dual-tracer autoradiographic study with 201Tl and 1251-MIBG was performed to investigate changes in the distribution of cardiac sympathetic innervation with the progression of cardiomyopathy in BIO 14.6 hamsters. The distribution of 201Tl was uniform in control hamsters and BIO 14.6 hamsters at all stages of cardiomyopathy. In contrast, a reduction in MIBG accumulation occurred in the endocardial region of the left ventricular free wall and the left ventricular aspect of the interventricular septum in BIO 14.6 hamsters at 3 and 8 months of age. Thus, there was an uncoupling of the left ventricular distribution of 201T1 and 125I-MIBG in BIO 14.6 hamsters. In addition, interstitial fibrosis was increased in the interventricular septum, the subendocardial region of the left ventricular free wall, and the right ventricular wall, which were the sites of reduced MIBG accumulation. This study shows that dual myocardial imaging with MIBG and 201Tl may be useful for investigating patients with cardiomyopathy |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
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収録物識別子 |
00471828 |
| EISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13474839 |
| 出版社DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1253/jcj.57.1089 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JCircJ-57-1089.pdf (1.3 MB)
