| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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タイトル |
EFFECTS OF L-CARNITINE ON TISSUE LEVELS OF ACYL CARNITINE, ACYL COENZYME A AND HIGH ENERGY PHOSPHATE IN ISCHEMIC DOG HEARTS |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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主題 |
L-carnitine |
| キーワード |
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主題 |
Ischemic dog heart |
| キーワード |
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主題 |
Long chain acy1 carmitine |
| キーワード |
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主題 |
Long chain acy1 CoA |
| キーワード |
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主題 |
Adenosine triphosphate |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Suzuki, Yoshikazu
Kamikawa, Tadashi
Kobayashi, Akira
Masumura, Yoshinori
Yamazaki, Noboru
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| 書誌情報 |
Japanese Circulation Journal
巻 45,
号 6,
p. 687-694,
発行日 1981-06-20
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| 出版者 |
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出版者 |
日本循環器学会 |
| 権利 |
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権利情報 |
Copyright日本循環器学会 |
| 権利 |
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権利情報 |
本文データは学協会の許諾に基づきJournal Archiveから複製したものである |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In order to evaluate the protective effects of L-carnitine on ischemic myocardium, its effects on tissue levels of acyl carnitine, acyl coenzyme A (CoA) and high energy phosphate were studied in ischemic dog hearts. Myocardial ischemia was induced by the ligation of left anterior descending coronary artery for 15 minutes. L-carnitine ( 100 mg/kg) was administered intravenously prior to coronary ligation. In ischemic myocardium, tissue levels of free carnitine decreased from 1043 ± 358 to 623 ± 180 n mol/g (p<0.001). On the other hand, long chain acyl carnitine increased from 214 ± 54 to 498 ± 149 n mol/g (p<0.001) and long chain acyl CoA increased from 15.7 ± 4.8 to 23.2 ± 5.4 n mol/g (p<0.01 ). Pretreatment of L-carnitine increased tissue levels of free carnitine to 863 ± 318 n mol/g (p<0.005) and decreased long chain acyl carnitine and long chain acyl CoA to 368 ±128 n mol/g (p<0.02) and 19.2 ± 6.5 n mol/g (p<0.1) respectively. Tissue levels of adenosine triphosphate (ATP) that was reduced by myocardial ischemia from 5.43± 0.67 to 2.80 ± 0.58 μ mol/g (p<0.001) was increased to 3.28 ± 0.63 μ mol/g (p< 0.02) by L-carnitine. Positive correlation was observed between ATP and free carnitine (p<0.01). On the other hand, negative correlation was observed not only between ATP and the ratio of long chain acyl CoA to free carnitine but also between ATP and the ratio of long chain acyl carnitine to free carnitine (p<0.01 respectively). These results suggest that the accumulation of long chain acyl carnitine may play an important role on cellular damage in ischemic myocardium and that administration of exogenous L-carnitine is beneficial for the protection of ischemic myocardium, probably because it reduces the accumulation of long chain acyl carnitine as well as long chain acyl CoA. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00471828 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13474839 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1253/jcj.45.687 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JCircJ-45-687.pdf (807.2 kB)
