| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
Stunned Myocardium and Oxygen Free Radicals : Sarcolemmal membrane damage due to oxygen free radicals : 54th Annual Scientific Session of the Japanese Circulation Society |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
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|
主題 |
Stunned myocardium |
| キーワード |
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|
主題 |
Free radicals |
| キーワード |
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|
主題 |
Heart sarcolemmal membrane |
| キーワード |
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|
主題 |
Calcium |
| キーワード |
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|
主題 |
Adrenergic receptors |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kaneko, Masanori
Hayashi, Hideharu
Kobayashi, Akira
Yamazaki, Noboru
Naranjan, S. Dhalla
|
| 書誌情報 |
Japanese Circulation Journal
巻 55,
号 9,
p. 885-892,
発行日 1991-09-20
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| 出版者 |
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出版者 |
日本循環器学会 |
| 権利 |
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|
権利情報 |
Copyright日本循環器学会 |
| 権利 |
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|
権利情報 |
本文データは学協会の許諾に基づきJournal Archiveから複製したものである |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
"Reperfusion after reversible ischemia has been shown to result in prolonged depression of contractile function (""myocardial stunning""). Recent studies suggest that oxygen free radicals may mediate postischemic dysfunction. Since heart sarcolemmal membranes, which contain several types of enzymes. ion channels and receptors play important roles to maintain cell functions, the pre-sent study was undertaken to examine the effects of oxygen free radicals on heart sarcolemmal membrane functions in vitro. In the presence of a superoxide anion radical-generating system (2mM xanthine plus 0.03 U/ml xanthine oxidase), sarcolemmal Ca2+-stimulated ATPase activity and ATP-dependent Ca2+ accumulation were inhibited in an incubating time-dependent manner. Both lipid peroxidation (r=0.82) and sulthydryl group content (r=0.95) showed significant correlations with Ca2+-stimulated ATPase activity. ATP-indenpendent Ca2+ bindings were increased upon treating the membranes with xanthine plus xanthine oxidase. Voltage-dependent Ca2+-channels were also affected by oxygen free radicals. The maximal number of binding sites (Bmax) for [3H]-nitrendipine binding was depressed without any changes in dissociation constant (Kd). The effects of oxygen free radicals on adrenergic receptors were more complex. Bmax for [3H]-dihydroalprenolol (DHA) binding (β-receptor) was increased whereas Bmax for [3H]-prazosin binding (α1-receptor) was de-creased after incubating the membrane with xanthine plus xanthine oxidase. Kd for [3H]-DHA or [3H]-prazosin binding was increased. Superoxide dismutase showed protective effects on the changes in these membrane functions due to xanthine plus xanthine oxidase. It is suggested that oxygen free radicals damage heart sarcolemmal mambrane functions which may lead to cardiac dysfunction. in the stunned myocardium." |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00471828 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13474839 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1253/jcj.55.885 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JCircJ-55-885.pdf (796.1 kB)
