| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
MYOCARDIAL FREE CARNITINE AND FATTY ACYLCARNITINE LEVELS IN PATIENTS WITH CHRONIC HEART FAILURE |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Carnitine |
| キーワード |
|
|
主題 |
Free carnitine |
| キーワード |
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|
主題 |
Long-chain acylcarnitine |
| キーワード |
|
|
主題 |
Myocardium |
| キーワード |
|
|
主題 |
Chronic heart failure |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Masumura, Yoshinori
Kobayashi, Akira
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Circulation Journal
巻 54,
号 12,
p. 1471-1476,
発行日 1990-12-20
|
| 出版者 |
|
|
出版者 |
日本循環器学会 |
| 権利 |
|
|
権利情報 |
Copyright日本循環器学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJournal Archiveから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
To study the tissue carnitine level in patients with chronic heart failure, we obtained biopsy specimens of the left ventricular papillary muscle from 8 patients with mitral valve disease undergoing valve replacement surgery. As a control group autopsy specimens from 7 patients without heart disease were obtained within 4 hours of death. The free carnitine level in the heart was significantly lower in patients with chronic heart failure than in the control group (412±142 nmol/g wet tissue vs 769±267; p<0.01, mean±SD). The long-chain acylcarnitine level was significantly higher in chronic heart failure than in the control group (532±169 nmol/g wet tissue vs 317±72; p<0.01). The total carnitine level in chronic heart failure was similar to that in the control group (1321±170 nmol/g wet tissue vs 1315±377) . These results show that in failing myocardium the fatty acid metabolism may be impaired, and administration of carnitine may be worth trying to treat chronic heart failure. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00471828 |
| EISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13474839 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1253/jcj.54.12_1471 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JCircJ-54-1471.pdf (707.9 kB)
