| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
L-Carnitine Treatment for Congestive Heart Failure : Experimental and clinical study : CURRENT THERAPY OF INTRACTABLE HEART FAILURE |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
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|
主題 |
Carnitine |
| キーワード |
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|
主題 |
Long-chain acylcarnitine |
| キーワード |
|
|
主題 |
Heart failure |
| キーワード |
|
|
主題 |
Myocardial metabolism |
| キーワード |
|
|
主題 |
Cardiomyopathy |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kobayashi, Akira
Masumura, Yoshinori
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Circulation Journal
巻 56,
号 1,
p. 86-94,
発行日 1992-01-20
|
| 出版者 |
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出版者 |
日本循環器学会 |
| 権利 |
|
|
権利情報 |
Copyright日本循環器学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJournal Archiveから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
To evaluate the therapeutic efficacy of l-carnitine in heart failure, the myocardial carnitine levels and the therapeutic efficacy of l-carnitine were studied in cardiomyopathic BIO 14.6 hamsters and in patients with chronic congestive heart failure and ischemic heart disease. BIO 14.6 hamsters and patients with heart failure were found to have reduced myocardial free carnitine levels (BIO 14.6 vs FI, 287±26.0 vs 384.8±83.8 nmol/g wet weight, p<0.05; patients with heart failure vs without heart failure, 412±142 vs 769±267 nmol/g p<0.01). On the other hand, long-chain acylcarnitine level was significantly higher in the patients with heart failure (532±169 vs 317±72 nmol/g, p<0.01). Significant myocardial damage in BIO 14.6 hamsters was prevented by the intraperitoneal administration of l-carnitine in the early stage of cardiomyopathy. Similarly, oral administration of l-carnitine for 12 weeks significantly irnproved the exercise tolerance of patients with effort angina. In 9 patients with chronic congestive heart failure, 5 patients (55%) moved to a lower NYHA class and the over-all condition was improved in 6 patients (66%) after treatment with l-carnitine. L-carnitine is capable of reversing the inhibition of adenine nucleotide translocase and thus can restore the fatty acid oxidation mechanism which constitutes the main energy source for the myocardium. Therefore, these results indicate that l-carnitine is a useful therapeutic agent for the treatment of congestive heart failure in combination with traditional pharmacological therapy. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00471828 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13474839 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1253/jcj.56.86 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JCircJ-56-86.pdf (1.1 MB)
