| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Neonatal Serum Deoxycorticosterone Sulfate Levels in Congenital Adrenal Hyperplasia due to 11β-Hydroxylase Deficiency |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
11β-hydroxylase deficiency (11β-0HD), |
| キーワード |
|
|
主題 |
deoxycorticosterone (DOC), |
| キーワード |
|
|
主題 |
Deoxycorticosterone ulfate (DOC sulfate), |
| キーワード |
|
|
主題 |
neonate |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Endoh, Akira
Ogawa, Haruo
Igarashi, Yoshio
Akira, Kubota
|
| 書誌情報 |
Clinical Pediatric Endocrinology
巻 2,
号 1,
p. 21-26,
発行日 1993-01-11
|
| 出版者 |
|
|
出版者 |
日本小児内分泌学会 |
| 権利 |
|
|
権利情報 |
The Japanese Society for Pediatric Endocrinology |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJournal Archiveから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Recent studies have demonstrated that deoxycorticosterone sulfate can be formed at extra-adrenal sites, but its actual origin and role are not yet clear. The present study was undertaken to elucidate the origin of deoxycorticosterone sulfate and the usefulness of this steroid for the diagnosis of 11β-hydroxylase deficiency in the early neonatal period. We measured serum deoxycorticosterone sulfate levels during glucocorticoid therapy in an infant with 11β-hydroxylase deficiency. Before therapy, the serum deoxycorticosterone sulfate concentration at 6 days of life was higher than normal. Following glucocorticoid therapy, the serum deoxycorticosterone sulfate concentration showed a marked and dose-dependent suppression, as did the serum deoxycorticosterone and 11-deoxycortisol levels. These findings suggest that serum deoxycorticosterone sulfate can be used as another specific indicator for the diagnosis of 11β-hydroxylase deficiency in neonates, and that the adrenal glands may play an important role in neonatal deoxycorticosterone sulfate production under the control of ACTH |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09185739 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13477358 |
| 出版社DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1297/cpe.2.21 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
Clinical P-2-21.pdf (1.2 MB)
