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新しい中大脳動脈血栓モデルにおける各種抗血栓薬の評価
http://hdl.handle.net/10271/2531
http://hdl.handle.net/10271/2531506d3223-8e00-4721-a074-4ce42b39a4c9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
rinsyouyakuri108-1-41.pdf (4.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2013-08-27 | |||||||
| タイトル | ||||||||
| タイトル | 新しい中大脳動脈血栓モデルにおける各種抗血栓薬の評価 | |||||||
| 言語 | ja | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
梅村, 和夫
× 梅村, 和夫
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| 書誌情報 |
日本薬理学雑誌 巻 108, 号 supplement, p. 41-46, 発行日 1996 |
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| 出版者 | ||||||||
| 出版者 | 日本臨床薬理学会 | |||||||
| 権利 | ||||||||
| 権利情報 | 日本薬理学会 | |||||||
| 権利 | ||||||||
| 権利情報 | 本文データは学協会の許諾に基づきJournal Archiveから複製したものである | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | In this study, the thrombotic occlusion of the middle cerebral artery (MCA) was induced by photochemical reaction between Rose Bengal and green light which causes endothelial injury followed by platelet adhesion, aggregation and formation of a platelet and fibrin-rich thrombus at the site of photochemical reaction. Using this model, we have investigated effects of antithrombotic agents, thrombolytic agents and neuroprotective agents. A thromboxane A2 receptor antagonist, ADP-induced platelet aggregation inhibitor and a selective thrombin inhibitor-inhibited the MCA thrombogenesis, suggesting that platelets play a key role in MCA thrombosis in this model. A tissue-type plasminogen activator (tPA), administered intravenously 30 min after the MCA occlusion could induce reopening of the thrombotically occluded artery, resulting in reduction of cerebral infarction size 24 h after the tPA administration. A glutamate release inhibitor and AMPA/kainate receptor antagonist, administered after the MCA occlusion reduced the size of cerebral infarction 24 h after the MCA occlusion. Using a microdialysis technique, glutamate concentration in the ischaemic border zone was measured and glutamate release was induced following cerebral ischaemia. This suggests that an increase in glutamate concentration in ischaemic border zone may play a key role in the development of cerebral infarction. | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 00155691 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 13478397 | |||||||
| 出版社DOI | ||||||||
| 関連タイプ | isIdenticalTo | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1254/fpj.108.supplement_41 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
