| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
創薬のための新しい病態モデル |
|
言語 |
ja |
| 言語 |
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|
言語 |
jpn |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
中島, 光好
梅村, 和夫
滝口, 祥令
|
| 書誌情報 |
日本薬理学雑誌
巻 102,
号 3,
p. 191-199,
発行日 1993
|
| 出版者 |
|
|
出版者 |
日本臨床薬理学会 |
| 権利 |
|
|
権利情報 |
日本薬理学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJournal Archiveから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Development of novel drugs relies on research to discover new drugs. Testing and evaluating new drugs on human subjects are usually impossible because of ethical concerns. Therefore, for drug discovery research, it is essential to establish animal models of human diseases. Numerous animal models have been developed and used in drug discovery and evaluation studies. Such animal models have had important roles in developing new drugs as well as understanding the etiologies of diseases. In the field of cardiovascular drugs, several interesting animal models are currently in use. These include, transgenic mice carrying both human renin and human angiotensinogen genes, Watanabe's heritable hyperlipidemic rabbits, rats with pulmonary hypertension induced by monocrotaline, myocardial infarction model, cardial hypertrophy model and photochemical thrombosis models. It is envisaged that for drug discovery and development, the search for more physiological animal models will continue in the future. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00155691 |
| EISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13478397 |
| 出版社DOI |
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|
関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
|
|
関連識別子 |
10.1254/fpj.102.191 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
rinsyouyakuri102-191.pdf (25.8 MB)
