| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Differential expression of KCC2 accounts for the differential GABA responses between relay and intrinsic neurons in the early postnatal rat olfactory bulb Ionization Mass Spectrometry |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
GABA |
| キーワード |
|
|
主題 |
Electrospray Ionization |
| キーワード |
|
|
主題 |
olfactory bulb |
| キーワード |
|
|
主題 |
cation-chloride cotransporter |
| キーワード |
|
|
主題 |
granule cell |
| キーワード |
|
|
主題 |
mitral cell |
| キーワード |
|
|
主題 |
KCC2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Wang, Cong
Ohno, Koji
Furukawa, Tomonori
Ueki, Takatoshi
Ikeda, Masahiko
Fukuda, Atsuo
Sato, Kohji
|
| 書誌情報 |
en : European Journal of Neuroscience
巻 21,
号 5,
p. 1449-1455,
発行日 2005-03
|
| 出版者 |
|
|
出版者 |
Blackwell Publishing |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The rat olfactory bulb is anatomically immature at birth and considerable neurogenesis and synaptogenesis are known to take place postnatally. In addition, significant physiological changes have also been reported in this period. For example, granule cell-mediated inhibition following electrical stimulations to the lateral olfactory tract is robust during the first postnatal week, then subsequently and abruptly decreases after the second week. However, the mechanism(s) underlying this enhanced inhibition remains to be elucidated. To know the cause of this phenomenon, we investigated the expression patterns of cation-Clcotransporters (KCC1, KCC2, and NKCC1) mRNAs, that are responsible for the regulation of [Cl-]i. In addition, GABA responses were measured by gramicidin-perforated patch-clamp recordings and Ca2+ imaging using fura-2. We found that, in the early postnatal period, mitral cells expressing KCC2 mRNA were inhibited by GABA, while granule cells lacking KCC2 mRNA expression were depolarized or excited by GABA. These results indicate that transient GABA-mediated excitation on granule cells might be the main cause of the enhanced inhibition onto mitral cells, and suggest that this differential GABA responses between relay and intrinsic neurons play pivotal roles in the early postnatal rat olfactory bulb. |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0953-816X |
| EISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1460-9568 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
15813956 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/j.1460-9568.2005.03975.x |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
EJN25(2005) .pdf (1.2 MB)
