| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-07-30 |
| タイトル |
|
|
タイトル |
Intrathecal cocaine delivery enables long-access self-administration with binge-like behavior in mice |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
addiction |
| キーワード |
|
|
主題 |
diurnal |
| キーワード |
|
|
主題 |
rhythm |
| キーワード |
|
|
主題 |
cocaine |
| キーワード |
|
|
主題 |
locomotion |
| キーワード |
|
|
主題 |
mice |
| キーワード |
|
|
主題 |
microdialysis |
| キーワード |
|
|
主題 |
relapse |
| キーワード |
|
|
主題 |
self-administration |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Nakamura, Masato
Gao, Shuibo
Okamura, Hitoshi
Nakahara, Daiichiro
|
| 書誌情報 |
Psychopharmacology
巻 213,
号 1,
p. 119-129,
発行日 2011-01
|
| 出版者 |
|
|
出版者 |
Springer |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Rationale: Long-access intravenous drug self-administration shows diurnal alterations in drug intake, with escalation and binge patterns, in rats. A similar long-access model in mice would allow the use of genetically modified animals to better understand the molecular mechanisms underlying drug addiction and relapse. However, attempts to transfer this model to mice have been less successful, mainly because of technical difficulties with long-term maintenance of the indwelling catheter implanted into small veins. Objectives: We devised an intrathecal probe implanted in the supracerebellar cistern as an alternative for intravenous drug administration to address this challenge and allow continuous, chronic drug self-administration in mice. Results: We found that mice readily self-administered intrathecal infusions of cocaine as a drug reward, and, under daily 24-h access conditions, animals exhibited a binge-like behavior comparable to rats. Conclusions: This innovation enables a full analysis of long-access drug self-administration behavior in mice not possible with intravenous administration. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00333158 |
| NII書誌ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00792709 |
| 出版社DOI |
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|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s00213-010-2021-6 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Psychop_213_119.pdf (2.3 MB)
