| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-07-30 |
| タイトル |
|
|
タイトル |
Cocaine enhances resistance to extinction of responding for brain-stimulation reward in adult prenatally stressed rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
cocaine |
| キーワード |
|
|
主題 |
intracranial |
| キーワード |
|
|
主題 |
self-stimulation |
| キーワード |
|
|
主題 |
medial forebrain bundle |
| キーワード |
|
|
主題 |
prenatal stress |
| キーワード |
|
|
主題 |
reward |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Gao, Shuibo
Suenaga, Toshiko
Oki, Yutaka
Yukie, Masao
Nakahara, Daiichiro
|
| 書誌情報 |
Behavioural brain research
巻 223,
号 2,
p. 411-416,
発行日 2011-10
|
| 出版者 |
|
|
出版者 |
Elsevier B.V. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The present experiment assessed whether prenatal stress (PS) can alter the ability of acute and chronic cocaine administration to increase and decrease the rewarding effectiveness of the medial forebrain bundle (MFB) using intracranial self-stimulation (ICSS), and also whether PS can affect the extinction of the MFB stimulation response. Adult male offspring of female rats that received PS or no PS (nPS) were implanted with MFB stimulating electrodes, and were then tested in ICSS paradigms. In both nPS and PS offspring, acute cocaine injection decreased ICSS thresholds dose-dependently. However, the threshold-lowering effects at any dose were not significantly different between groups. There was also no group-difference in the threshold-elevating effects of chronic cocaine administration. Nevertheless, chronically drug-administered PS rats exhibited a resistance to the extinguishing of the response for brain-stimulation reward when acutely treated with cocaine, as compared to extinction without cocaine treatment. The results suggest that PS may weaken the ability for response inhibition under cocaine loading in male adult offspring. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
01664328 |
| NII書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00108669 |
| 出版社DOI |
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|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.bbr.2011.04.030 |
| 著者版フラグ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Behavi_223_411.pdf (316.8 kB)
