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Interindividual variations in aprepitant plasma pharmacokinetics in cancer patients receiving cisplatin-based chemotherapy for the first time
http://hdl.handle.net/10271/2708
http://hdl.handle.net/10271/2708e94c7ee0-d43a-4893-9d9e-22b4a9dfcb14
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (578.6 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2014-04-09 | |||||||
| タイトル | ||||||||
| タイトル | Interindividual variations in aprepitant plasma pharmacokinetics in cancer patients receiving cisplatin-based chemotherapy for the first time | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | aprepitant | |||||||
| キーワード | ||||||||
| 主題 | pharmacokinetics | |||||||
| キーワード | ||||||||
| 主題 | total bilirubin | |||||||
| キーワード | ||||||||
| 主題 | serum albumin | |||||||
| キーワード | ||||||||
| 主題 | cytochrome P450 3A5 | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | シスプラチンベースの初回化学療法を受けるがん患者でのアプレピタントの血漿中薬物動態の個体差 | |||||||
| 著者 |
Motohashi, Shinya
× Motohashi, Shinya
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| 書誌情報 |
en : Biological and Pharmaceutical Bulletin 巻 36, 号 4, p. 676-681, 発行日 2013 |
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| 出版者 | ||||||||
| 出版者 | 日本薬学会 | |||||||
| 言語 | ja | |||||||
| 出版者 | ||||||||
| 出版者 | The Pharmaceutical Society of Japan | |||||||
| 言語 | en | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報 | Copyright 2013 The Pharmaceutical Society of Japan | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The pharmacokinetics of aprepitant, a neurokinin-1 receptor antagonist, have not been fully evaluated in clinical settings. The aim of this study was to characterize the plasma pharmacokinetics of aprepitant and reveal their influence of laboratory tests and cytochrome P450 (CYP) 3A5 gene polymorphisms in cancer patients. Forty-four Japanese cancer patients receiving cisplatin-based chemotherapy for the first time following oral aprepitant (125 mg on day 1 and 80 mg on days 2 and 3) were enrolled. The patients did not have gastrointestinal disease and the clinical laboratory values were within their normal reference levels. The plasma concentrations of aprepitant 24 (day 2 predose), 72, and 120 hours after the first aprepitant administration were determined using LC-MS/MS. The relationships between plasma exposure to aprepitant and body weight, clinical laboratory values, age, gender, or CYP3A5*3 were investigated. The median and interquartile ranges of the 120-h area under the plasma concentration time curve (AUC)0-120 of aprepitant were 73215 and 55518-91121 ngh/mL. The coefficient of variation value for aprepitant AUC0-120 was 53%. The AUC0-120 of aprepitant was correlated with the levels of total bilirubin and serum albumin, respectively (r=0.454, p<0.01 and r=0.287, p=0.06), but not with other non-genetic factors and CYP3A5 genetic variants in a univariate analysis. The AUC0-20 of aprepitant was significantly correlated with the level of total bilirubin (adjusted R2=0.187, p<0.01) in a multivariate analysis. In conclusion, the plasma pharmacokinetics of aprepitant varied markedly in cancer patients receiving cisplatin-based chemotherapy for the first time and were correlated with the level of total bilirubin. | |||||||
| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2013-04-19 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第656号 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0918-6158 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1347-5215 | |||||||
| PubMed番号 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 23370406 | |||||||
| 医中誌論文ID | ||||||||
| 識別子タイプ | ICHUSHI | |||||||
| 関連識別子 | 2013307648 | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1248/bpb.b12-01086 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
