Distribution of late gadolinium enhancement in end-stage hypertrophic cardiomyopathy and dilated cardiomyopathy : differential diagnosis and prediction of cardiac outcome

Machii, Masashi

doi:https://doi.org/10.1016/j.mri.2013.10.011

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Distribution of late gadolinium enhancement in end-stage hypertrophic cardiomyopathy and dilated cardiomyopathy : differential diagnosis and prediction of cardiac outcome

http://hdl.handle.net/10271/2782

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論文本文 (474.9 kB)

Item type

学位論文 / Thesis or Dissertation(1)

公開日

2015-01-09

タイトル

Distribution of late gadolinium enhancement in end-stage hypertrophic cardiomyopathy and dilated cardiomyopathy : differential diagnosis and prediction of cardiac outcome

言語

eng

キーワード

主題

dilated cardiomyopathy

キーワード

主題

end-stage hypertrophic cardiomyopathy

キーワード

主題

late gadolinium enhancement

キーワード

主題

cardiac magnetic resonance

キーワード

主題

reverse remodeling

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_db06

資源タイプ

doctoral thesis

アクセス権

open access

アクセス権URI

http://purl.org/coar/access_right/c_abf2

その他のタイトル

終末期肥大型心筋症および拡張型心筋症におけるガドリニウム遅延造影の分布：鑑別診断と心予後の予測

著者

Machii, Masashi

書誌情報

en : Magnetic Resonance Imaging

巻 32, 号 2, p. 118-124, 発行日 2014

出版者

ELSEVIER

抄録

内容記述タイプ

Abstract

内容記述

Background- The prognostic implications of late gadolinium enhancement (LGE) have been evaluated in ischemic and non-ischemic cardiomyopathies. The present study analyzed LGE distribution in patients with end-stage hypertrophic cardiomyopathy (ES-HCM) and with dilated cardiomyopathy (DCM), and tried to identify high risk patients in DCM.
Methods- Eleven patients with ES-HCM and 72 with DCM underwent cine- and LGE-cardiac magnetic resonance and ultrasound cardiography. The patient outcome was analyzed retrospectively for 5 years of follow-up.
Results- LGE distributed mainly in the inter-ventricular septum, but spread more diffusely into other left ventricular segments in patients with ES-HCM and in a certain part of patients with DCM. Thus, patients with DCM can be divided into three groups according to LGE distribution; no LGE (n=24), localized LGE (localized at septum, n=36), and extensive LGE (spread into other segments, n=12). Reverse remodeling occurred after treatment in patients with no LGE and with localized LGE, but did not in patients with extensive LGE and with ES-HCM. The event-free survival rate for composite outcome (cardiac death, hospitalization for decompensated heart failure or ventricular arrhythmias) was lowest in patients with extensive LGE (92%, 74% and 42% in no LGE, localized LGE, and extensive LGE, p=0.02 vs. no LGE), and was comparable to that in patients with ES-HCM (42%).
Conclusions- In DCM, patients with extensive LGE showed no functional recovery and the lowest event-free survival rate that were comparable to patients with ES-HCM. The analysis of LGE distribution may be valuable to predict reverse remodeling and to identify high-risk patients.

言語

学位名

博士（医学）

学位の区分

内容記述

doctoral

学位の分野

内容記述

医学系研究科

学位授与機関

学位授与機関識別子Scheme

kakenhi

学位授与機関識別子

13802

学位授与機関名

浜松医科大学

学位授与年月日

2014-03-07

学位授与番号

甲第667号

ISSN

収録物識別子タイプ

PISSN

収録物識別子

0730-725X

EISSN

収録物識別子タイプ

EISSN

収録物識別子

1873-5894

PubMed番号

識別子タイプ

PMID

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2023-06-20 17:04:39.935056

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Distribution of late gadolinium enhancement in end-stage hypertrophic cardiomyopathy and dilated cardiomyopathy : differential diagnosis and prediction of cardiac outcome

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