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Short-term drug-drug interaction between sildenafil and bosentan under long-term use in patients with pulmonary arterial hypertension
http://hdl.handle.net/10271/2783
http://hdl.handle.net/10271/2783f1ca89df-33dc-44c2-a2ff-628678d00f52
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (865.8 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2015-01-09 | |||||||
| タイトル | ||||||||
| タイトル | Short-term drug-drug interaction between sildenafil and bosentan under long-term use in patients with pulmonary arterial hypertension | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | Drug-Drug Interaction | |||||||
| キーワード | ||||||||
| 主題 | Pulmonary Arterial Hypertension | |||||||
| キーワード | ||||||||
| 主題 | Sildenafil | |||||||
| キーワード | ||||||||
| 主題 | Bosentan | |||||||
| キーワード | ||||||||
| 主題 | Pharmacokinetics | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | 肺動脈性肺高血圧症患者における長期的なシルデナフィルとボセンタン使用下での両薬物の短期的薬物間相互作用 | |||||||
| 著者 |
Miyakawa, Sachiko
× Miyakawa, Sachiko
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| 書誌情報 |
en : Pharmacology & Pharmacy 巻 4, 号 7, p. 542-548, 発行日 2013 |
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| 出版者 | ||||||||
| 出版者 | Scientific Research Publishing | |||||||
| 言語 | en | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Sildenafil and bosentan are often co-administered for pulmonary arterial hypertension (PAH) treatment. The plasma concentration of sildenafil can be decreased by half if co-administered with bosentan. Many patients take these agents simultaneously in the morning and the evening. The aim of this study was to examine the pharmacokinetics of sildenafil which was interfered with bosentan administration to ascertain whether these agents should be given concomitantly or separately. A two-way crossover study was conducted in 6 PAH patients with combination therapy of sildenafil and bosentan. Participants underwent the sequence of treatment phases: phase S (sildenafil administered 3 h before bosen-tan); phase B (bosentan administered 3 h before sildenafil); and phase C (administered concomitantly). Blood samples were collected on the last day of each phase. There was no significant difference in maximum plasma concentration or area under the plasma concentration-time curve (AUC0-8) between phase C and phase S (95.5±24.8 vs. 72.9±40.9 (p=0.07), 209.7±81.8 vs. 180.2±126.4 (p=0.24), respectively) or between phases C and B (87.8±42.0 vs. 99.6±33.9 (p=0.59), 197.2±88.2 vs. 240.7±121.8 (p=0.19), respectively) (ng/mL, mean±standard deviation). Large intra- and inter-individual variability in sildenafil concentration was noted. The timing of administration of sildenafil and bosentan does not significantly influence the plasma concentration of sildenafil. Physicians do not need to be overly concerned about the timing of administration of these drugs to maximize the sildenafil concentration. | |||||||
| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2014-03-17 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第672号 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 2157-9423 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2157-9431 | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.4236/pp.2013.47078 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
