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Type-1 polarized dendritic cells are a potent immunogen against Mycobacterium tuberculosis
http://hdl.handle.net/10271/3220
http://hdl.handle.net/10271/32207dd2b1f1-b951-4896-aea7-6fe5948de420
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (1.1 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2018-03-06 | |||||||
| タイトル | ||||||||
| タイトル | Type-1 polarized dendritic cells are a potent immunogen against Mycobacterium tuberculosis | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | IL-12 | |||||||
| キーワード | ||||||||
| 主題 | IFN-γ | |||||||
| キーワード | ||||||||
| 主題 | vaccine | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | タイプ1免疫誘導型樹状細胞は結核菌に対して強力な免疫原性を有する | |||||||
| 著者 |
Satake, Yasuomi
× Satake, Yasuomi
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| 書誌情報 |
en : The International Journal of Tuberculosis and Lung Disease 巻 21, 号 5, p. 523-530, 発行日 2017-05-01 |
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| 出版者 | ||||||||
| 出版者 | International Union Against Tuberculosis and Lung Disease | |||||||
| 言語 | en | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | OBJECTIVE: Application of immunotherapy using dendritic cells (DCs) is considered an effective treatment strategy against persistent Mycobacterium tuberculosis infection. With the goal of developing improved therapeutic vaccination strategies for patients with tuberculosis (TB), we tested the ability of ex vivo-generated DCs to induce an effective TB antigen-specific type-1 immune response. METHODS: Monocyte-derived DCs from TB patients were induced to mature using a “standard” cytokine cocktail (IL-1β, TNF-α, IL-6, and PGE2) or a type 1-polarized DC (DC1) cocktail (IL-1β, TNF-α, IFN-α, IFN-γ, and polyinosinic:polycytidylic acid), and were loaded with the established TB antigen 6-kDa early secretory antigenic target protein (ESAT-6). RESULTS: Although DC1s from TB patients expressed the same levels of multiple co-stimulatory molecules (CD83, CD86, CD80, CD11c, and CD40) as the standard DCs (sDCs), DC1s secreted substantially higher levels of IL-12p70. Furthermore, when DCs pulsed with or without ESAT-6 were cultured with lymphocytes from the same patients, DC1s induced much higher numbers of ESAT-6-specific IFN-γ-producing T cells than sDCs, as manifested by their superior induction of natural killer cells activation and antigen-independent suppression of regulatory T cells. CONCLUSION: TB antigen-loaded DC1s are potent inducers of antigen-specific T cells, which could be used to develop improved immunotherapies of TB. |
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| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2017-03-13 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第746号 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 1027-3719 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1815-7920 | |||||||
| PubMed番号 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 28399967 | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.5588/ijtld.16.0371 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
