| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Glycine cleavage system in neurogenic regions |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
glycine |
| キーワード |
|
|
主題 |
glycine cleavage system |
| キーワード |
|
|
主題 |
non-ketotic hyperglycinemia |
| キーワード |
|
|
主題 |
rat |
| キーワード |
|
|
主題 |
neural stem cell |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Ichinohe, Akiko
Kure, Shigeo
Mikawa, Sumiko
Ueki, Takatoshi
Kojima, Kanako
Fujiwara, Kazuko
Iinuma, Kazuie
Matsubara, Yoichi
Sato, Kohji
|
| 書誌情報 |
en : European Journal of Neuroscience
巻 19,
号 9,
p. 2365-2370,
発行日 2004-03
|
| 出版者 |
|
|
出版者 |
Blackwell Publishing |
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The glycine cleavage system (GCS) is the essential enzyme complex for degrading glycine and supplying 5,10-methylenetetrahydrofolate for DNA synthesis. Inherited deficiency of this system causes non-ketotic hyperglycinemia, characterized by severe neurological symptoms and frequent association of brain malformations. Although high levels of glycine have been considered to cause the above-mentioned problems, the detailed pathogenesis of this disease is still unknown. Here we show that GCS is abundantly expressed in rat embryonic neural stem/progenitor cells in the neuroepithelium, and this expression is transmitted to the radial glia-astrocyte lineage, with prominence in postnatal neurogenic regions. These data indicate that GCS plays important roles in neurogenesis, and suggest that disturbance of neurogenesis induced by deficiency of GCS may be the main pathogenesis of non-ketotic hyperglycinemia |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0953-816X |
| EISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1460-9568 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
15128390 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/j.0953-816X.2004.03345.x |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
EJN-19_2004.pdf (675.7 kB)
