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Distinct spatial localization of three types of phosphatidyl choline in rat buccal mucosa identified by matrix-assisted laser desorption/ionization imaging mass spectrometry
http://hdl.handle.net/10271/00003669
http://hdl.handle.net/10271/00003669bb51f63a-889e-4df3-9c7b-d4734e9c1f54
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (5.7 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2019-12-05 | |||||||
| タイトル | ||||||||
| タイトル | Distinct spatial localization of three types of phosphatidyl choline in rat buccal mucosa identified by matrix-assisted laser desorption/ionization imaging mass spectrometry | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | imaging mass spectrometry | |||||||
| キーワード | ||||||||
| 主題 | buccal mucosa | |||||||
| キーワード | ||||||||
| 主題 | phosphatidylcholine | |||||||
| キーワード | ||||||||
| 主題 | mass microscopy | |||||||
| キーワード | ||||||||
| 主題 | matrix assisted laser desorption/ionization | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | マトリックス支援レーザー脱離イオン化質量分析イメージングにより明らかになったラット頬粘膜における3種類のリン脂質の異なる分布 | |||||||
| 著者 |
宮城, 摩里子
× 宮城, 摩里子
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| 書誌情報 |
en : Medical Mass Spectrometry 巻 1, 号 1, p. 2-9, 発行日 2017-06 |
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| 出版者 | ||||||||
| 出版者 | 日本医用マススペクトル学会 | |||||||
| 言語 | ja | |||||||
| 出版者 | ||||||||
| 出版者 | Japannese Society for Biomedical Mass Spectrometry | |||||||
| 言語 | en | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | The buccal mucosa is an inner lining exposed to frequent friction caused by teeth occlusion and therefore, a vulnerable site to lesions such as stomatitis, leukoplakia, lichen planus and cancer. Although it is considered an important tissue in the field of oral surgery, not enough information regarding the buccal mucosa is available. In this study, we characterized the buccal mucosa in the oral cavity using imaging mass spectrometry (IMS). Tissues such as epithelium, lamina propria and muscle were identified in rat buccal mucosa by HE staining. Moreover, IMS data of high-intensity ions were classified into 4 groups according to their distribution. In a previous IMS analysis of mouse tongue tissue, we detected linoleic acid-containing phosphatidyl choline (PC)(diacyl 16:0/18:2), oleic acid-containing PC(diacyl 16:0/18:1) and DHA-containing PC(diacyl 16:0/22:6) as major PCs. In the present work, we analyzed buccal mucosa tissue with emphasis on the aforementioned PC by IMS and showed that the investigated PCs existed in the layers of epithelium, lamina propria, and muscle at different ratios. This is the first study to analyze by IMS the buccal mucosa. The results presented here are likely to provide the perspective on understanding oral environments and to develop treatments for oral disorders. | |||||||
| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2019-03-13 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第805号 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 2432-7441 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2432-745X | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.24508/mms.2017.06.002 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
