{"_buckets": {"deposit": "93942f5c-da1c-4c8e-ae60-248e8a5efa1f"}, "_deposit": {"created_by": 4, "id": "3552", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "3552"}, "status": "published"}, "_oai": {"id": "oai:hama-med.repo.nii.ac.jp:00003552", "sets": ["73"]}, "author_link": ["10381", "10382", "10383", "10384", "10385", "10386", "10387", "10388", "10389", "10390", "10391", "10392", "10393", "10394", "10395", "10396", "10397", "10398", "10399", "10400"], "item_3_biblio_info_5": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "14", "bibliographicPageStart": "3", "bibliographicVolumeNumber": "9", "bibliographic_titles": [{"bibliographic_title": "静岡産科婦人科学会雑誌", "bibliographic_titleLang": "ja"}]}]}, "item_3_description_30": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_3_description_9": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "悪性腫瘍治療後に白血病を発症することがあり、治療関連白血病と呼ばれている。再発子宮平滑筋肉腫に対して放射線療法・化学療法施行後に治療関連慢性骨髄性白血病を発症した1例を経験した。\n症例は45歳女性。径15 cmの子宮腫瘍のため、子宮を全摘した。手術1年後に溶骨型腰椎腫瘍と左鎖骨上リンパ節腫大を認め、生検の結果、子宮平滑筋肉腫の再発と診断され、腰椎病変に対する放射線照射と化学療法を施行した。化学療法終了8か月後より白血球数が増加し始め、1年後には71000 /μLにまで上昇した。精査の結果、慢性骨髄性白血病(慢性期)と診断した。Nilotinibが奏効し、再発無く経過している。悪性腫瘍に対して化学療法、放射線療法を行った後は、原病フォローだけではなく、二次発がんとして治療関連白血病の可能性も念頭に置いて定期的な血液検査を行うことが重要である。", "subitem_description_language": "ja", "subitem_description_type": "Abstract"}, {"subitem_description": "Chemotherapy or radiation therapy for malignant tumors can induce leukemia, known as therapy-related leukemia. We report a case of therapy-related chronic myelogenous leukemia that developed after palliative radiotherapy and chemotherapy for recurrent metastatic uterine leiomyosarcoma. The patient, a 45-year-old Japanese woman was referred to our institution for a 15-cm uterine mass. We performed total hysterectomy. One year after the operation, we found an osteolytic tumor in the lumbar vertebra and left supraclavicular lymphadenopathy. Based on further pathological evaluation of the bone tumor, the uterine leiomyosarcoma had recurred and metastasized to the lumbar vertebra and left supraclavicular lymph node. After palliative radiation to the lumbar spine following posterior lumbar spinal fusion, she was administered adriamycin, gemcitabine with docetaxel, and ifosfamide, resulting in partial remission. One years later, her white blood cell count were increased to 71000 / μL. Bone marrow pathology demonstrated an increase in neutrophils at all stages of maturation and chromosomal examination led to the diagnosis of chronic-phase chronic myelogenous leukemia. She was treated using nilotinib, a tyrosine kinase inhibitor, and achieved the optimal course without recurrence. However, the primary uterine leiomyosarcoma was poorly controlled, with metastases in the brain, left femur, and left foot bone. During follow-up after chemotherapy and radiation therapy for malignant tumors, it is important to regularly measure the complete blood count and biochemical markers keeping in mind not only recurrence of the primary tumor, but also the development of secondary malignancy such as treatment-related leukemia.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_3_publisher_6": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "静岡産科婦人科学会", "subitem_publisher_language": "ja"}]}, "item_3_select_2": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_select_item": "Journal Article", "subitem_select_language": "en"}]}, "item_3_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "21871914", "subitem_source_identifier_type": "ISSN"}]}, "item_3_version_type_32": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小田, 智昭", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10381", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "榎並, 輝和", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10382", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "柏木, 唯衣", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10383", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "土井, 貴之", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10384", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊藤, 敏谷", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10385", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "竹原, 啓", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10386", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "松本, 雅子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10387", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "井出, 瑠衣", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10388", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "松木, 翔太郎", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10389", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田, 智子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10390", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "井上, 結貴", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10391", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "加藤, 貴史", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10392", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "菊池, 卓", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10393", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "川合, 健太", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10394", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "矢田, 大輔", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10395", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "榛葉, 賴子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10396", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小田, 彩子", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10397", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "内田, 季之", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10398", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小宮山, 明", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10399", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "杉野, 隆", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "10400", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "jsog_9_1_3.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1000000.0, "url": {"url": "https://hama-med.repo.nii.ac.jp/record/3552/files/jsog_9_1_3.pdf"}, "version_id": "827e7ee5-3996-4706-8a7c-fbce75d17b66"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "therapy-related leukemia", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "chronic myelogenous leukemia", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "leiomyosarcoma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "chemotherapy", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "radiotherapy", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "子宮平滑筋肉腫の術後転移再発に対する化学療法および緩和的放射線療法後に治療関連慢性骨髄性白血病を発症した一例", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "子宮平滑筋肉腫の術後転移再発に対する化学療法および緩和的放射線療法後に治療関連慢性骨髄性白血病を発症した一例", "subitem_title_language": "ja"}, {"subitem_title": "Therapy-related chronic myelogenous leukemia after chemotherapy and palliative radiotherapy for postoperative metastatic leiomyosarcoma: A case report", "subitem_title_language": "en"}]}, "item_type_id": "3", "owner": "4", "path": ["73"], "permalink_uri": "http://hdl.handle.net/10271/00003685", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-03-24"}, "publish_date": "2020-03-24", "publish_status": "0", "recid": "3552", "relation": {}, "relation_version_is_last": true, "title": ["子宮平滑筋肉腫の術後転移再発に対する化学療法および緩和的放射線療法後に治療関連慢性骨髄性白血病を発症した一例"], "weko_shared_id": -1}