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Brain Activation in a Cynomolgus Macaque Model of Chymopapain-Induced Discogenic Low Back Pain: A Preliminary Study
http://hdl.handle.net/10271/00003727
http://hdl.handle.net/10271/00003727a436093b-c6b1-418d-ab74-b21e2fcb845d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (2.2 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2020-04-30 | |||||||
| タイトル | ||||||||
| タイトル | Brain Activation in a Cynomolgus Macaque Model of Chymopapain-Induced Discogenic Low Back Pain: A Preliminary Study | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | chymopapain | |||||||
| キーワード | ||||||||
| 主題 | discogenic low back pain | |||||||
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| 主題 | nonhuman primate | |||||||
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| 主題 | pressure test | |||||||
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| 主題 | brain activation | |||||||
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| 主題 | functional magnetic resonance imaging | |||||||
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| 主題 | secondary somatosensory cortex | |||||||
| キーワード | ||||||||
| 主題 | insular cortex | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | キモパパインを用いて誘発したカニクイザル椎間板性腰痛モデルにおける脳活動; 予備実験 | |||||||
| 著者 |
後迫, 宏紀
× 後迫, 宏紀
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| 書誌情報 |
en : Spine surgery and related research 巻 3, 号 4, p. 368-376, 発行日 2019-04-05 |
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| 出版者 | ||||||||
| 出版者 | Japanese Society for Spine Surgery and Related Research | |||||||
| 言語 | en | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Background: There is currently a lack of translatable, preclinical models of low back pain (LBP). Chymopapain, a proteolytic enzyme used to treat lumbar intervertebral disc (IVD) herniation, could induce discogenic LBP. The current study developed a behavioral model of discogenic LBP in nonhuman primates. Significant brain activation is observed in clinical LBP. Thus, the current study also sought to define brain activation over time in a macaque with discogenic LBP. Methods: Responses to pressure applied to the back at L4/L5 were measured in eight adult male Macaca fasciculata using a pressure algometer. The nucleus pulpous of the IVD between L4 and L5 was aspirated and chymopapain (1mg/mL) was injected under fluoroscopic guidance (n=2). In two macaques, the nucleus pulpous was only aspirated. Brain activation in response to pressure applied to the lower back was assessed using a 3.0T magnetic resonance imaging scanner in four macaques before and 1,3,9, and 14 days after treatment. Results: The mean (±SD) response pressure before treatment was 1.4±0.1kg. One day after chymopapain treatment, the response pressure decreased to 0.6±0.05kg (P<0.01), suggestive of pressure hypersensitivity. Over time, the pressure thresholds following chymopapain treatment gradually returned to normal. Following aspiration only, the response pressure was 1.4±0.05kg, which was not significantly different from the uninjured controls. There was activation of the secondary somatosensory cortex and insular cortex one and three days after chymopapain treatment; there was no activation following aspiration only. Conclusions: Enzymatic treatment of the nucleus pulpous leads to acute LBP and pressure-evoked activation in pain-related brain areas. The current model of discogenic LBP parallels clinical LBP and could be used to further elaborate the mechanism of acute LBP. |
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| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2020-03-16 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第832号 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 2432-261X | |||||||
| PubMed番号 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 31768458 | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.22603/ssrr.2018-0110 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
