| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Application of electrospray ionization tandem mass spectrometry for the rapid and sensitive determination of cobalt in urine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Cobalt |
| キーワード |
|
|
主題 |
Tandem mass spectrometry |
| キーワード |
|
|
主題 |
Electrospray ionization |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Minakata, Kayoko
Suzuki, Masako
Suzuki, Osamu
|
| 書誌情報 |
en : Analytica Chimica Acta
巻 614,
号 2,
p. 161-164,
発行日 2008-05-05
|
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利 |
|
|
権利情報 |
(C) Elsevier |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Recently, cobalt (Co) is reported to be taken as a supplement by athletes for improving anaerobic performance. For the diagnosis of abuse, the limit of detection (LOD) of Co in the analysis should be lower than the concentrations of Co in plasma and urine of normal persons. A simple, rapid and sensitive method has been developed for the determination of Co in urine. Co was complexed with diethyldithiocarbamate (DDC) and extracted with isoamyl alcohol in the presence of citric acid. The detection of Co was achieved by injecting a 1 μl aliquot of isoamyl alcohol containing Co-DDC complex directly into an electrospray ionization tandem mass spectrometric (ESI-MS-MS) instrument without chromatographic separation. The quantification was performed using selected reaction monitoring at m/z 291 of the product ion Co(C4H10NCS)2+ which was produced by collision-induced dissociation from the precursor ion Co(DDC)2+ at m/z 355. ESI-MS-MS data were obtained in less than 10 min with an LOD of 0.05 μgl-1 and a linear calibration range of 0.1 – 100 μgl-1 using 10 μl of urine. The procedure was validated with certified reference materials (SRM 2670a and SRM 1643e). This method is suitable for the analysis of Co in the laboratories already equipped with an ESI-MS-MS instrument. |
| ISSN |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0003-2670 |
| EISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1873-4324 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
18420046 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.aca.2008.03.043 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
ACA-07-1999Rev.pdf (168.3 kB)
