| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-02-15 |
| タイトル |
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タイトル |
1.2% Hydrogen gas inhalation protects the endothelial glycocalyx during hemorrhagic shock: a prospective laboratory study in rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
hydrogen |
| キーワード |
|
|
主題 |
hemorrhagic shock |
| キーワード |
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主題 |
endothelial glycocalyx |
| キーワード |
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|
主題 |
hydrogen gas concentration |
| キーワード |
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主題 |
inhalation |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sato, Tsunehisa
Mimuro, Soichiro
Katoh, Takasumi
Kurita, Tadayoshi
Truong, Sang Kien
Kobayashi, Kensuke
Makino, Hiroshi
Doi, Matsuyuki
Nakajima, Yoshiki
|
| 書誌情報 |
Journal of Anesthesia
巻 34,
号 2,
p. 268-275,
発行日 2020-04
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| 出版者 |
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出版者 |
Springer Nature |
| 権利 |
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権利情報 |
"This is a post-peer-review, pre-copyedit version of an article published in ""Journal of Anesthesia"". The final authenticated version is available online at: https://doi.org/10.1007/s00540-020-02737-3." |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: Hydrogen gas (H2) inhalation improved the survival rate of hemorrhagic shock. However, its mechanisms are unknown. We hypothesized that H2 protected the endothelial glycocalyx during hemorrhagic shock and prolonged survival time.
Methods: 83 Sprague?Dawley rats were anesthetized with isoflurane. The animals were randomly assigned to 5 groups: room air with no shock, 1.2% H2 with no shock, room air with shock (Control-S), 1.2% H2 with shock (H2 1.2%-S), and 3.0% H2 with shock (H2 3.0%-S). Shock groups were bled to a mean arterial pressure of 30 to 35 mmHg and held for 60 min, then resuscitated with normal saline at 4-fold the amount of the shed blood volume.
Results: The syndecan-1 level was significantly lower in the H2 1.2%-S [8.3 ± 6.6 ng/ml; P=0.01; 95% confidence interval (CI), 3.2?35.8] than in the Control-S (27.9 ± 17.0 ng/ml). The endothelial glycocalyx was significantly thicker in the H2 1.2%-S (0.15 ± 0.02 μm; P=0.007; 95% CI, 0.02?0.2) than in the Control-S (0.06 ± 0.02 μm). The survival time was longer in the H2 1.2%-S (327 ± 67 min, P=0.0160) than in the Control-S (246 ± 69 min). The hemoglobin level was significantly lower in the H2 1.2%-S (9.4 ± 0.5 g/dl; P=0.0034; 95% CI, 0.6?2.9) than in the Control-S (11.1 ± 0.8 g/dl). However, the H2 3.0%-S was not significant.
Conclusions: Inhalation of 1.2% H2 gas protected the endothelial glycocalyx and prolonged survival time during hemorrhagic shock. Therapeutic efficacy might vary depending on the concentration. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0913-8668 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1438-8359 |
| PubMed番号 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
PMID |
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関連識別子 |
31997005 |
| 出版社DOI |
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|
関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1007/s00540-020-02737-3 |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
J Anesth-34-268.pdf (1.2 MB)
