| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-04-26 |
| タイトル |
|
|
タイトル |
Nationwide study of pediatric B-cell precursor acute lymphoblastic leukemia with chromosome 8q24/MYC rearrangement in Japan |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
B-cell precursor acute lymphoblastic leukemia |
| キーワード |
|
|
主題 |
8q24/MYC rearrangement |
| キーワード |
|
|
主題 |
Burkitt lymphoma/leukemia |
| キーワード |
|
|
主題 |
immunophenotype |
| キーワード |
|
|
主題 |
double-hit lymphoma/leukemia |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sakaguchi, Kimiyoshi
Imamura, Toshihiko
Ishimaru, Sae
Imai, Chihaya
Shimonodan, Hidemi
Fujita, Naoto
Okada, Keiko
Taketani, Takeshi
Kanai, Rie
Tauchi, Hisamichi
Kato, Motohiro
Kojima, Yasuko
Watanabe, Arata
Deguchi, Takao
Hashii, Yoshiko
Kiyokawa, Nobutaka
Taki, Tomohiko
Saito, Akiko M.
Horibe, Keizo
Manabe, Atsushi
Sato, Atsushi
Koh, Katsuyoshi
|
| 書誌情報 |
Pediatric Blood & Cancer
巻 67,
号 7,
p. e28341,
発行日 2020-07
|
| 出版者 |
|
|
出版者 |
John Wiley & Sons |
| 権利 |
|
|
権利情報 |
"This is the peer reviewed version of the following article: ""Nationwide study of pediatric B-cell precursor acute lymphoblastic leukemia with chromosome 8q24/MYC rearrangement in Japan, Pediatric blood & cancer, 67(7): e28341, (2020)"". which has been published in final form at https://doi.org/10.1002/pbc.28341. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background
Rearrangements of chromosome 8q24/MYC (8q24/MYC-r), resulting from t(8;14)(q24;q32), t(2;8)(p11;q24), or t(8;22)(q24;q11), are mainly associated with Burkitt lymphoma/leukemia (BL) and rarely observed in patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The characteristics of BCP-ALL with 8q24/MYC-r are poorly understood.
Procedure
A retrospective nationwide study of data from patients with pediatric BCP-ALL with 8q24/MYC-r in Japan was conducted to clarify the clinical and biological characteristics associated with 8q24/MYC-r BCP-ALL.
Results
Ten patients with BCP-ALL with 8q24/MYC-r, including three with double-hit leukemia (DHL) (two with t(8;14)(q24;q32) and t(14;18)(q32;q21), and one with t(8;14) and t(3;22)(q27;q11)), were identified. Patients with BCP-ALL with 8q24/MYC-r had higher median age, and uric acid (UA) and lactate dehydrogenase (LDH) levels, than those without 8q24/MYC-r. All patients were initially treated with ALL-type chemotherapy; however, four, including one with DHL, were switched to BL-type chemotherapy, based on cytogenetic findings. One patient relapsed after standard-risk ALL-type chemotherapy, and two patients with DHL did not attain complete remission with chemotherapy; all three died within 11 months. The other seven patients treated with BL-type or high-risk ALL type chemotherapy are alive without disease.
Conclusions
The clinical and laboratory features of BL with IG-MYC rearrangement, displaying a BCP immunophenotype (Wagener et al. and Herbrueggen et al. termed it as preBLL), are similar to those of BCP-ALL with 8q24/MYC-r. Low-risk ALL-type chemotherapy may not be appropriate for them, and further studies are required to establish an adequate therapeutic strategy. Further studies of DHL to identify new treatment strategies are also needed. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1545-5009 |
| EISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1545-5017 |
| PubMed番号 |
|
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
32323914 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1002/pbc.28341 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Pediatr Blood Cancer-67-e28341.pdf (3.2 MB)
