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Tenascin C in the tumor-nerve microenvironment enhances perineural invasion and correlates with locoregional recurrence in pancreatic ductal adenocarcinoma
http://hdl.handle.net/10271/00003786
http://hdl.handle.net/10271/0000378664253ee0-2f3e-4d2a-a726-3615d6511f82
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (5.6 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2021-04-01 | |||||||
| タイトル | ||||||||
| タイトル | Tenascin C in the tumor-nerve microenvironment enhances perineural invasion and correlates with locoregional recurrence in pancreatic ductal adenocarcinoma | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | pancreatic ductal adenocarcinoma | |||||||
| キーワード | ||||||||
| 主題 | perineural invasion | |||||||
| キーワード | ||||||||
| 主題 | tenascin C | |||||||
| キーワード | ||||||||
| 主題 | dorsal root ganglion | |||||||
| キーワード | ||||||||
| 主題 | tumor-nerve microenvironment | |||||||
| キーワード | ||||||||
| 主題 | neurotropism | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | 腫瘍神経微小環境に発現するテネイシンCが、浸潤性膵管がんにおいて神経周囲浸潤を促進し、局所領域再発と相関する | |||||||
| 著者 |
古橋, 暁
× 古橋, 暁
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| 書誌情報 |
en : Pancreas 巻 49, 号 3, p. 442-454, 発行日 2020-03 |
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| 出版者 | ||||||||
| 出版者 | Wolters Kluwer Health | |||||||
| 言語 | en | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Objectives: Perineural invasion (PNI) is common in pancreatic ductal adenocarcinoma (PDAC) and worsens the postoperative prognosis. Tenascin C (TNC), an extracellular matrix glycoprotein, modulates tumor progression. We evaluated the functional roles of TNC, especially in PNI of PDAC. Methods: We examined immunohistochemical TNC expression in 78 resected PDAC specimens. The relationships between TNC expression and clinicopathological features were retrospectively analyzed. Interactions between cancer cells and TNC-supplemented nerves were investigated using an in vitro co-culture model with PDAC cell line and mouse dorsal root ganglion (DRG). Results: Tenascin C expression was predominant in perineural sites at invasive tumor front. High perineural TNC expression in 30 patients (38%) was associated with PNI, pathological T stage ? 3, and postoperative locoregional recurrence. High TNC expression was independently associated with postoperative, poor recurrence-free survival by multivariate analysis. In the in vitro co-culture model, a TNC-rich matrix enhanced both PDAC cell colony extensions toward nerves and DRG axonal outgrowth toward cancer cell colonies, whereas TNC did not affect axonal outgrowth or cancer cell proliferation in separately cultured DRG and PDAC cells. Conclusions: Strong perineural TNC expression indicated poor prognosis with locoregional recurrence. The neurotropism of TNC-induced PDAC suggests TNC is a potential PDAC therapeutic target. |
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| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2020-03-16 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第839号 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 0885-3177 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 1536-4828 | |||||||
| PubMed番号 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 32132519 | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1097/MPA.0000000000001506 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
